摘要
目的:观察牡丹皮对糖尿病大鼠前列环素(PGI2)、血栓素A2(TXA2)、内皮素(ET)、一氧化氮(NO)的影响。方法:采用腹腔注射链脲佐菌素60 mg/kg的方法制备糖尿病动物模型,然后分别以高、中、低等不同的剂量的牡丹皮对模型鼠进行灌胃,采用放射免疫法检测各组大鼠用药前后PGI、TXA2、ET、NO的变化。结果:结果显示,各用药组用药前后的血糖值无明显变化,与对照组相比,没有显著性差异。各用药组大鼠的ET值有所降低,其中以高剂量组最明显,与对照组相比,有显著性差异。各用药组大鼠的NO值稍有升高,但与对照组相比,没有显著性差异。各用药组大鼠的TXB2值有所降低,其中以高剂量组最明显。6-Keto-PGF1α值升高,与对照组相比,有显著性差异。结论:提示牡丹皮对糖尿病大鼠的ET、PGI2、TXA2均有一定的作用。
Objective ： To study the effect of Paeonol on PGI2 ,TXA2 ,ET and NO in diabetic rats. Methods ： Streptozocin was used on rats to make diabetic animal models. Different dosage of Paeonol were used on diabetic animal models. PGI2 TXA2 ,ET and NO were tested after 30 days therapy. Results： Compared with those in the control group, the level of PGI2 increased and the contents of TXA2 and ET decreased in treatment group. Among them, the high dosage group was more obvious （P〈0.01 ）. But the level of No Had no change. Conclusion： Paeonol can decrease the ET and TXA2 in diabetic rats, and increase PGI2 in diabetic rats.
出处
《中药材》
CAS
CSCD
北大核心
2007年第6期687-690,共4页
Journal of Chinese Medicinal Materials
基金
广东省中医药管理局资助项目(编号:1050036)
关键词
牡丹皮
糖尿病
血管内皮细胞
Cortex Moutan
Diabetes mellitus
Vessel endothelial cells
