摘要
目的:研究伤必止的药效学和毒理学。方法:采用热板法、扭体法、二甲苯致炎法及镜下观察小鼠耳廓微循环法研究伤必止的镇痛、抗炎、活血化淤作用;对健康家兔进行急性毒性试验、长期毒性试验、皮肤刺激性试验;对健康豚鼠进行皮肤过敏试验。结果:伤必止可提高小鼠痛阈,明显减少其扭体反应次数,抑制二甲苯所致的小鼠耳廓肿胀,使其中央静脉血管口径增大;对家兔完整及破损皮肤均未引起急性毒性反应和刺激反应,对家兔皮肤长期应用无毒性反应;对豚鼠无致敏作用。结论:伤必止具有较好的抗炎、镇痛、活血化淤作用,且安全无毒。
OBJECTIVE： To study the pharmacology and the toxicology of Shangbizhi. METHODS： The analgesic, anti-inflammatory, and blood-activating and stasis-eliminating actions of Shangbizhi were studied by hot plate method, body-twistlng method, inflammation method caused by dimethyl benzene, and the method of observing micro-circulation of mice＇s pinna under microscope. Acute toxicity test, long-term toxicity test and dermal irritation test were conducted in healthy rabbits, and dermal sensitivity test was performed in healthy guinea pigs. RESULTS： Shangbizhi could elevate mice＇s threshold of pain, markedly reduce the twisting times of mice, inhibit mice＇ s swelling of pinna caused by dimethyl benzene and enlarge its caliber of central veins. It showed no acute toxicity or irritation to the intact or damaged skin of rabbits; its long-term use had no toxicity on the skin of rabbits, and it caused no allergy to guinea pigs. CONCLUSION： Shangbizhi has satisfactory anti-inflammatory, analgesic, and blood-activating and stasis-eliminating actions, meanwhile it is safe and nontoxic.
出处
《中国药房》
CAS
CSCD
北大核心
2007年第21期1615-1617,共3页
China Pharmacy
关键词
伤必止
抗炎
镇痛
活血化淤
药效学
毒理学
Shangbizhi
anti-inflammatory
analgesia
blood-activating and stasis-eliminating
Pharmacology
Toxicology
作者简介
主管药师。研究方向：药物经济学、临床药学。电话：0771-2178891。Email：wangdongmei067@yahoo．com．cn
