摘要
目的了解系统性红斑狼疮(SLE)患者D-二聚体的水平及其临床价值。方法用单克隆抗体乳胶凝集试验法测定62例SLE患者血浆D-二聚体水平,研究其与SLE的疾病活动、临床表现的关系及治疗前后的变化。结果(1)SLE患者血浆D-二聚体水平较正常组显著增高(P<0.001);治疗后血浆D-二聚体水平较治疗前明显降低(P<0.05);(2)血浆D-二聚体水平与SLE DAI得分呈显著正相关(r=0.451,P<0.01);(3)血浆D-二聚体水平在初发患者中明显高于复发者(P<0.01),合并浆膜炎、白细胞降低及栓塞的患者分别显著高于无浆膜炎、白细胞正常及无栓塞的患者(均P<0.01);(4)抗心磷脂抗体阳性、抗dsDNA抗体阳性患者的血浆D-二聚体水平高于抗心磷脂抗体阴性、抗dsDNA抗体阴性者(分别为P<0.01,P<0.05);(5)SLE患者血浆D-二聚体水平与血沉呈正相关(r=0.428,P<0.001),与补体C3水平呈负相关(r=-0.275,P<0.05)。结论SLE患者血浆D-二聚体检测有助于SLE疾病活动性和临床疗效的评估。
Objective To study the clinical significance of plasma D-dimer in patients with systemic lu- pus erythematosus （SLE）. Methods The levels of plasma D-dimer in 62 SLE patients were measured by monoclonal antibody latex agglutination test. Results The levels of D-dimer in SLE patients were significantly higher than those in the controls（P〈0.001 ）, the levels of plasma D-dimer were significantly decreased （P〈0.05） in 10 patients and after the treatment. The levels were showed a significant positive correlation with SLEDAI scores（r=0.572,P〈0.001 ）. The levels of plasma D-dimer in SLE patients who were the first time at- tacked with SLE were significantly higher than those in SLE patients with recrudescence （P〈0.01）. The levels of plasma D-dimer in SLE patients with serositis, leucopenia, thrombosis were significantly higher than those without these clinical manifestations（P〈0.01 ）. The levels of plasma D-dimer in SLE patients with anti-double- stranded DNA positive group were significantly higher than those in the negative group, meanwhile the levels of plasma D-dimer in SLE patients with anticardiolipid antibodies positive group were significantly higher than those in the negative group. There was a significantly positive correlation between levels of plasma D-dimer and ESR（r=0.428,P〈0.001 ）,and a negative correlation between levels of plasma D-dimer and C3 levels（r=- 0.275 ,P〈0.05）. Conclusion Levels of plasma D-dimer in SLE patients is valuable for assessment of disease activity and the rapeutic effect.
出处
《现代实用医学》
2007年第3期181-184,共4页
Modern Practical Medicine
作者简介
郑小庆（1983-），女，浙江省衢州市人，医师。
