摘要
去乙酰化酶Sir2基因家族对细胞的生存、凋亡、衰老等生理活动起着十分重要的调节作用,可能是所有生物共同的寿命控制基因之一。去乙酰化酶(SIRT1)是SIR2的同源物,以许多非组蛋白和组蛋白为底物,与代谢综合征、基因稳定性、肿瘤,神经退行性疾病的发生相关。能量限制可通过增加SIRT1活性来延长啮鼠动物的寿命。因此,SIRT1可作为治疗不同疾病的靶点逐渐被人们所重视。
The silent information regulator protein 2 （ Sir2 ） and its homologues play an important role in the regulation of cellular physiological processes such as survival, apoptosis, and aging. SIRT1, the mammalian Sir 2 homologue, has been shown to deacetylate a wide range of non-histone substrates and histone substrates. It has been constantly reported that SIRT1 may be associated with the occurrence of metabolic syndrome, genomic homeostasis, tumors, and neurodegenerative diseases. Calorie restriction may mitigate many major diseases in rodent models by SIRTl-mediated deacetylase activity and prolong the life expectancies in these animals. Therefore, SIRT1 may be emphasized as a new therapy target for many different diseases.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2007年第3期441-447,共7页
Acta Academiae Medicinae Sinicae
基金
国家重点基础研究发展计划项目(973计划)(2006CB503801)~~
关键词
去乙酰化酶
能量限制
衰老
deaeetylase
calorie restriction
ageing
作者简介
通信作者：刘德培电话：010—65296415，传真：010-65105093，电子邮件：liudp@pumc．edu．cn
