摘要
目的:探讨一步制粒机中影响清开灵颗拉孔隙率的因素;方法:采用一步制拉法对影响孔隙的因素进行试验;结果:对孔隙率影响大小的顺序为供液速率>排风频率>进风温度,并在优选的条件下试硷,发现润湿粘附剂的浓度与孔隙率成反比;结论:采用一步制粒技术可形成孔隙率大的颗粒,大大提高了药物的溶出速率。
Objective： In order to discuss the factor of one - step - granulating＇s influence on the Qingkailing granules porsity. Methods： We had an experiment with one - step - granulating. Results： the sequence of influencing porosity is that the rate of supplying liquid 〉 the frequency of obviating wind 〉 the temperature of putting in wind, the chroma of wetting agent conglutination and porosity show inversc ratio under the test of handpicked condition. Conclusion ：with one- step - granulating we could get the granules with much larger poroity to raise the rate of dissolution.
出处
《黑龙江医药》
CAS
2007年第4期344-345,共2页
Heilongjiang Medicine journal
关键词
一步制粒
孔隙率
清开灵颗粒
工艺研究
one - step - granulating
porosity
Qinkailing granules
research of arts and crafts
