摘要
目的研究血浆脑利钠肽(BNP)浓度与心脏射血分数(EF)、左室收缩(LVSD)及舒张内径(LVED)、左室后壁及室间隔厚度、左房内径、心功能的关系。方法对547例患者测定血浆脑利钠肽浓度,行超声心动图检查,测量心脏射血分数、左室后壁及室间隔厚度、左室收缩及舒张内径、左房内径。结果547例患者BNP值均数为(558.5±838.08)pg/ml。有305例做了心超检查,其中测EF值304例,作E、A峰比较214例,窦性心律388例,房颤者154例。病情恶化29例,好转512例。LGBNP(BNP值以10为底的对数值)与EF值呈显著负相关,与左室后壁及室间隔厚度、左室收缩及舒张内径、左房内径、心功能显著相关;在房颤和窦性心律的病人中LGBNP相关不显著。在病情好转及恶化的病人中LGBNP相关显著。结论血浆BNP水平能较好地反映心衰病人的心功能及心脏结构的状况。
Objective To find out the relationship between plasmatic levels of brain natriuretic peptide （BNP） and echocardiographic indicators： EF, LVDs, LVDd LVWP, IVS, LAD and heart function. Methods 547 patients received both BNP test and echocardiography examination. Ejection fraction（EF）, thickness of left ventricle posterior wall （LVPW） and interventricular septum （IVS）, diameters of left ventricle during systolic and diastolic phase（ LVDs and LVDd）, and diameters of left atrium（LAD） were measured. Results The average value of BNP of all the 547 patients is 558.5 ±838.08pg/ml, 305 patients received echocardiography examination. Among them, values of EF of 304 cases were measured, E and A peak values of 214 cases were compared, 388 patients were of sinus rhythm, 154 patients were of atrial fibrillation, 29 patients were exacerbated and 512 patients were mended. The levels of brain natriuretic peptide （BNP） were negatively correlated with the values of ejection fraction （EF）. The levels of BNP also showed correlations with LVPW, IVS, LVDs＆LVDd, LAD and heart funtion. The values of BNP showed no significant difference between patients with sinus rhythm and those with atrial fibrillation, the values of BNP were also significantly different between pations who were mended and those who were exacerbated. Conclusion The level of BNP is a good prdictor for heart function and structure of patients with heart failure.
出处
《中国微循环》
北大核心
2007年第3期195-197,共3页
Journal of Chinese Microcirculation
关键词
心功能
脑利钠肽
心室重构
Heart funtion
Brain natriuretic peptide （BNP）
Ventricular reconstruction
作者简介
吴学明（1964-），男，汉族，江苏无锡人，副主任医师．副主任。研究方向：心血管介入诊疗及心衰治疗。
