摘要
目的对复方红花滴丸的制备工艺进行考察。方法采用正交实验法研究成型的最佳工艺条件。结果以PEG6000作为基质,液体石蜡为冷却剂,药物与辅料以1∶5配比,料温70℃,滴口内外径1.2/1.3(内/外,mm/mm),滴距100 mm,滴速20滴/m in,梯度冷却为最佳制备条件。结论该工艺可为复方红花滴丸的制备提供实验依据。
Objective To study the preparation technology of Compound Safflower Dropping Pills. Methods Orthogonal test was applied to optimize the preparation of Compound Safflower Dropping Pills. Results The optimized project was as follow： the matrix contained PEG6000;the refrigerant was liquid paraffir,the rate of the drug to maxtrix was l： 5 and the temperature of the drug was 70℃, The internal and external diameter of burette was 1. 2mm and 1.3mm,respectively, the burette was lOOmm above the surface of refrigerant, and the drug was dropped into Gradient cooling refrigerant at 20 drops per minute. Conclusion The results provide the data for the ascertainment of shaping operation of Compound Safflower Dropping Pills at the manufacturing scale.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2007年第3期635-637,共3页
Lishizhen Medicine and Materia Medica Research
关键词
复方红花滴丸
正交实验
制备工艺
Safflower Dropping Pills
Orthogonal test
Preparation
作者简介
于莲（1960-），女（汉族），黑龙江佳木斯人，现任佳木斯大学化学与药学院教授，学士学位，主要从事中药新制剂与新剂型方向的研究.
