摘要
目的探讨代谢紊乱患者脂联素水平和内皮依赖性血管舒张功能(EDF)的关系。方法100例患者根据代谢紊乱的数目,分为无代谢紊乱组(对照组,M0)、1项代谢紊乱组(M1)、2项代谢紊乱组(M2)和代谢综合征组(M3)。采用高分辨率血管外彩色超声测定肱动脉内径,以肱动脉反应性充血前后血管内径变化百分比反映EDF,并测定脂联素、一氧化氮(NO)、一氧化氮合成酶(NOS)、内皮素-1(ET-1)的水平。结果随着代谢紊乱数目的增多,BMI、SBP、TG、FINS、HOMA-IR呈增高趋势,HDL-C呈降低趋势,各组间比较差异有显著意义(P<0.05或P<0.01)。M2组和M3组EDF、NO、NOS下降,ET-1升高,与M0组比较差异有显著意义(P<0.05或P<0.01);M3组ET-1与M2组比较差异有显著意义(P<0.05);M3组NO、NOS、ET-1与M1组比较差异有显著意义(P<0.05);M3组脂联素水平与HOMA-IR呈负相关(r=-0.516,P<0.05)。结论脂联素可能通过影响内皮细胞NOS活性、NO和ET-1的分泌,维持正常内皮细胞的功能。
Objective To investigate the relationship between the levels of adiponectin and endothelium-dependent diastolic function（EDF） in patients with metabolic disorder. Methods 100 patients with metabolic disorder were randomly divided into four groups： non-metabolic disorder group （M0）, one-item metabolic disorder group （ M1 ）, two-item metabolic disorders group （M2） and metabolic syndrome group （ M3 ）. The inner diameter of brachial artery was measured by high-resolution ultrasound system before and after reactive hyperemia, and blood adiponectin, blood concentrations of NO, NOS and ET-1 were detected. Results With the increase of the items of metabolic disorder, BMI, SBP, TG, FINS, HOMA-IR presented the tendency of increase, however, HDL-C presented the tendency of decrease, there were significant differences among groups （ P 〉 0.05 or P 〈 0.01 ）. Threre was a significant difference in ET-1 between group M3 and group M2 （ P 〈 0.05）;there were significant differences in NO, NOS,ET-1 between group M3 and group Mx ;the levels of adiponectin were negatively correlated with HOMA-IR （ r = -0.516, P 〈 0.05）. Conclusion Adiponectin can maintain normal endothelial function by affecting the activity of NOS and secretion of NO and ET-1.
出处
《疑难病杂志》
CAS
2007年第6期327-329,共3页
Chinese Journal of Difficult and Complicated Cases
关键词
脂联素
代谢综合征
血管内皮功能
Adiponectin
Metabolic syndrome
Endothelium function
作者简介
通讯作者：王虹，E-mail：wanghongabc@tom．com
