摘要
目的观察并分析采用连续皮下胰岛素输注方法(胰岛素泵的强化治疗)治疗2型糖尿病(T2DM)高血糖状态的疗效以及剂量。方法67例血糖控制差的住院T2DM患者,给予胰岛素泵强化治疗,不合用其他口服降糖药,观察达到满意血糖控制(FBG<7mmol/L,2hBG<10mmol/L)的天数以及胰岛素泵的总量和基础量,并分析与上述指标相关的因素。结果血糖达满意控制的平均天数为(6.45±3.47)天,胰岛素的日最大剂量为(62.99±18.58)U/kg或(1.09±0.34)U/kg,基础量为(28.11±8.35)U/kg或(0.49±0.15)U/kg。发生低血糖症(0.15±0.56)次/人。结论经过胰岛素泵的强化治疗,T2DM的高血糖状态可在6～7天得以纠正。经相关分析,影响达目标血糖时间的因素为糖化血红蛋白HbA1c,影响胰岛素用量的因素为体重和HbA1c。
Objective To investigate and analyze effect and insulin dosage of continuous subcutaneous insulin infusion （ CS Ⅱ ） in type 2 diabetes. Methods 67 hospitallized patients with type 2 diabetes, who had poorly controlled blood glucose treated by insulin pump, without oral hypoglycemicagents. It is observed trestment days when blood glucose was well controlled and the insulin dose. There lated foctors for the therapeutic effects were analyzed. Results The mean time when blood glucose were well controlled was （6.45 ±3.47） days, the total insulin was （62. 99 ± 18.58） or （ 1.09 ± 34） U/kg, the basel insulin was （28.11 ± 8.35 ） U/kg or （0. 49 ± 0. 15 ） U/kg. the frequency of biochemical hypoglycemia was （0. 15 ± 0. 56 ） （times/ perpatient） . Conclusion The hyperglycemia of type 2 diabetes could be corrected by intensive insulin pump within 6- 7 days. Correlative analysis showed that the time when blood glucose were well controlled correlated with HbA1c the insulin dose correlated with HbA1c and weight.
出处
《广州医药》
2007年第3期24-26,共3页
Guangzhou Medical Journal
