摘要
目的:研究甘薯糖蛋白SPG-1对H22荷瘤小鼠的抗肿瘤作用及免疫调节作用。方法:从“广薯98”中提取SPG-1,通过灌胃给药,研究SPG-1对H22荷瘤小鼠的抑瘤率、存活期、肿瘤细胞有丝分裂指数和脾脏指数、胸腺指数、腹腔巨噬细胞活性的影响。结果:SPG-1对H22实体瘤小鼠具有明显的抑瘤作用(p＜0．05),对H22腹水瘤小鼠具有明显的延长存活期作用(p＜0．05),对H22腹水瘤小鼠的肿瘤细胞有丝分裂具有非常明显的抑制作用(p＜0．01);SPG-1能明显增加H22实体瘤小鼠的脾脏指数(p＜0．01)、胸腺指数(p＜0．05),能明显增强H22实体瘤小鼠的腹腔巨噬细胞活性(p＜0．01)。结论:SPG-1对H22荷瘤小鼠具有明显的抗肿瘤作用且能明显增强H22荷瘤小鼠的免疫功能。
Object： To study the antitumor and immune activity of SPG-1 on H22 tumor mice. Methods： Sweet potato glycoprotein （SPG-1） was extracted from the cultivar Guangdong 98. The kunming H22 fumor mice were given SPG-1 by intragastrical injection （i.g.） then the inhibiting rate of tumor growth, life prolongation rate, karyokinesis index of tumor cells, spleen index, thymus index and the activity on macrophage of celiac plexus were studied. Results： SPG-1 can significantly inhibit the tumor growth （p〈0.05） on H22 entity-tumor mice, significantly prolong life （p〈0.05） on H22 bearing-tumor mice. SPG-1 can obviously inhibit karyokinesis of tumor cells （p 〈 0.01） on H22 bearing-tumor mice, and notably enhanced the spleen index （p 〈 0.01）, the thymus index （p 〈 0.05 ） and the activity on macrophage of celiac plexus （o 〈 0.01） on H22 entity-tumor mice.Conclusion： SPG-I has anti-tumor and immune function on H22 tumor mice.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2007年第5期312-316,共5页
Food Science
关键词
甘薯
糖蛋白
抗肿瘤
免疫调节
sweet potato
glycoprotein
anti-tumor
immunoregulation
作者简介
刘主（1977-），男，讲师，硕士，研究方向为生物化学与分子生物学。
通讯作者
