摘要
目的研究初次发病的腔隙性脑梗死(LI)不同时段、病变部位与认知功能的关系。方法136例初次发病的LI患者,于发病后72h内、2周、1个月、3个月、6个月时进行神经心理测试,观察不同时段、部位与认知的关系,并与76例正常人进行比较。结果记忆力:72h内,各部位(基底节、放射冠、额叶、颞叶、顶叶、侧脑室旁、半卵圆中心、丘脑)LI与对照组相比有显著性差异(P<0.05);2周、1个月、3个月时,某些部位与对照组相比有显著性差异(P<0.05);6个月时所有部位与对照组相比无显著性差异(P>0.05)。语言:72h、2周和1个月时,所有部位的语言评分与对照组相比有显著性差异(P<0.05);3个月、6个月时,某些LI部位与对照组相比有显著性差异(P<0.05)。实践能力:2周、1个月、3个月、6个月各时段评分与对照组相比均有显著性差异(P<0.05)。注意力:72h内,各部位与对照组相比有显著性差异(P<0.05);2周、1个月、3个月和6个月时,某些部位的注意力与对照组相比有显著性差异(P<0.05)。定向力:LI对定向力影响不显著。结论初次发病的LI在疾病不同时段各个部位都损害了认知功能,定向力保留,提示LI与认知障碍关系密切,值得重视和干预。
Objective To explore the characters of cognitive dysfunction for first-ever lacunar infarction （LI）. Methods 136 first-ever diagnosed LI patients were evaluated with Alzheimer＇s disease assessment scale （ADAS） 72 h, 2 weeks, 1 month, 3 months and 6 months after attack. The scores were compared with the baseline and those of 76 normal control. Results Memory： during the first 72 h, significant difference was shown between the every location of LI （including the basal ganglia, corona radiate, frontal lobe, temporal lobe, parietal lobe, periventricular location, centrum semiovale, thalamus） and normal control （P〈0.05） ; but between the certain location of LI and that of normal control 2 weeks, 1, 3 and 6 months after attack （P〈0.05）. Language： there was significant difference between every location of LI and normal control 72 h, 2 weeks and 1 month after attack （P〈0.05）, but between the certain location of LI and that of normal control 3 and 6 months after attack （P〈0.05）. Practice： there was significant difference through every visit time point of all the LI patients compared with normal control （P〈0.05）. Attention： Significant difference （P〈0.05） was found between every location LI patients and normal control 72 h after attack, but between certain location LI patients and normal control 2 weeks, 1, 3 and 6 months after attack （P〈0.05）. Orientation：LI was insufficient to cause to decline in orientation. Conclusion There are mild to severe cognitive dysfunctions in the first-ever diagnosed LI patients, which need pay attention to and intervene in time.
出处
《中国康复理论与实践》
CSCD
2007年第5期407-409,共3页
Chinese Journal of Rehabilitation Theory and Practice
关键词
腔隙性脑梗死
认知功能
记忆
语言
实践
注意
定向力
lacunar infarction
congnitive function
memory
language
practice
attention
orientation
作者简介
赵建功（1969-），男，北京市人，硕士，主治医师，主要研究方向：脑血管病的认知状况。
