摘要
目的:探讨基质金属蛋白酶3(MMP-3)和尿激酶型纤溶酶原激活物受体(uPAR)在2型糖尿病大血管病变中的变化。方法:用ELISA双抗体夹心法测定26例正常对照和39例2型糖尿病患者(其中单纯2型糖尿病15例、合并大血管病变24例)的血浆MMP-3和uPAR水平。结果:单纯糖尿病组uPAR高于正常对照(P<0.05)而MMP-3无显著差异;合并大血管病变组MMP-3显著高于正常对照和单纯糖尿病组(P<0.01,P<0.01),而uPAR亦高于正常对照及单纯病变组(P<0.01,P<0.05)。2型糖尿病血浆MMP-3水平和uPAR水平呈正相关,LDL-C与uPAR呈正相关且是uPAR主要影响因素。结论:MMP-3和uPAR与2型糖尿病大血管病变发生密切相关,MMP-3可作为2型糖尿病血管病变的循环标志物。
AIM： To investigate the function of matrix metalloproteinase -3 （MMP-3） and urokinase -type plasminogen activator receptor （uPAR） to macroangiopathy in type 2 diabetes mellitus. METHODS： The levels of MMP - 3 and uPAR in plasma were determined by ELISA sandwich method in 26 healthy controls and 39 patients with type 2 diabetes mellitus including 15 complication - free cases and 24 with macroangiopathy. RESULTS ： The plasma level of uPAR but not MMP - 3 was higher in patients without macroangiopathy than that in normal controls （P 〈 0. 05 ）. In patients with macroangiopathy, the plasma levels of MMP - 3 and uPAR were higher than those in normal controls （P 〈 0. 01 ） and patients without angiopathy. There was positive relationship between MMP - 3 and uPAR in type 2 diabetes mellitus （ r = 0. 405, P 〈0. 05）, and LDL - C was the important affecting factor of uPAR. CONCLUSION： MMP - 3 and uPAR are associated with the development of macroangiopathy in type 2 diabetes mellitus. MMP - 3 can be regarded as the circulatory markers in type 2 diabetes mellitus with macroangiopathy.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2007年第5期897-899,共3页
Chinese Journal of Pathophysiology
基金
浙江省卫生厅科学基金资助项目(No.491020-W00602)
关键词
基质金属蛋白酶
受体
尿纤溶酶原激活物
糖尿病
非胰岛素依赖型
动脉硬化
Matrix metalloproteinases
Receptors, urinary plasminogen activator
Diabetes mellitus, non - insulin - dependent
Arteriosclerosis
