摘要
为了解纯化人白细胞α－干扰素（ＩＦＮ－α）治疗早期（≤５病日）确诊的肾综合征出血热（ＨＦＲＳ）疗效及其意义。对２３例，在临床转归及抗病毒方面进行观察，均显著优于随机对照的２１例患者。治疗前及治疗后２、４、６、８、１０天各留血、尿标本，检测外周血单个核细胞（ＰＢＭＣ）和尿液中病毒膜蛋白（ＭＰ）与核蛋白（ＮＰ），血清抗－ＭＰ和抗－ＮＰ。结果治疗组ＰＢＭＣ中ＭＰ和ＮＰ表达明显受到抑制，至治疗后第１０天６５．２２％（１５／２３例）ＭＰ转阴，６９．５７％（１６／２３例）ＮＰ转阴，对照组为１９．０５％（４／２１例），１４．２９％（３／２１例）；尿ＭＰ与ＮＰ转阴率为７８．５７％（１１／１４例）和９０．９１％（１０／１１例），对照组为３０．００％（３／１０例）和１６．６６％（１／６例）。两组比较差异非常显著（Ｐ＜０．０１）。表明ＩＦＮ－α通过抑制病毒表达，减轻病毒的直接损伤，而使病情改善和提高治愈率。
In order to know the therapeutic effect of purified human leucocytic interferon α on hemorrhagic fever with renal syndrome diagnosed early (≤5 days). We treated 23 cases with clinical prognosis and antiviral effect significantly better than those of 21 cases in a random control group. The membrane protein (MP), nucleo protein (NP) in peripheral blood mononuclear cells (PBMC) and urine, the serum antibodies to MP and NP were determined before treatment and 2, 4, 6, 8, 10 days after the beginning of the treatment. The results showed that in the treatment group, the expressin of MP and NP in PBMC were significantly depressed. The rate of negative turning of MP and NP in PBMC was 65.22% (15/23) and 69.57% (16/23) in 10 days, while in the control group, it was 19.05% (4/21) and 14.29% (3/21) . The rate of negative turning of MP and NP in urine were 78.57% (11/14) and 90.91% (10/11) and that in the control group was 30.00% (3/10) and 16.66% (1/6). There was a significant difference between the two groups ( P <0.01). The results indicated that IFN α could attenuate the lesions caused directly by virus, improve patients condition and raise the cure rate through depressing the expression of the virus.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1997年第2期90-93,共4页
Chinese Journal of Internal Medicine
关键词
肾综合征出血热
干扰素Α
药物疗法
Hemorrhagic fever with renal syndrome Interferon alpha Viral matrix proteins
