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中国河南汉族人群D19S253、D12S391和D18S535位点基因多态性检测 被引量：1

Genetic polymorphism of D19S253,D12S391 and D18S535 in Henan Han population
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摘要 目的:探讨中国河南汉族人群中D19S253、D12S391和D18S535等3个STR位点的遗传多态性。方法:对80份河南汉族无关个体的EDTA抗凝血样,采用PCR和PAGE技术进行检测,并构建等位基因梯阶。结果:3个位点的等位基因分布均符合Hardy-Weinberg平衡,杂合度均大于0.763,个体识别力均大于0.904,非父排除率均高于0.531,多态信息含量均高于0.730。结论:中国河南汉族人群中此3个STR位点具有很高的遗传多态性,可用于法医学个体识别和亲权鉴定。 Aim： To explore the genetic polymorphism of D19S253, D12S391 and D18S535 in Henan Han population. Methods： A total of 80 unrelated individuals from Han population in Henan were subjected to detect the allele frequencies（AF） of D19S253, D12S391, D18S535, and observed heterogosity（HO）, discrimination power（DP）, polymorphic information content（PIC） and power of exclusion （PE） were calculated. Results： All loci were found no deviation from Hardyeinberg equilibrium. HO of the three loci were all more than 0. 763, DP were more than 0. 904 ,PE were more than 0.531 ,and PIC were more than 0.730. Conclusion： These 3 loci have high DP values and can be used for forensic personal identification and paternity tests.
作者 赵美乐 曾昭书 郑旭东 齐守文 黄代新 刘良
机构地区 华中科技大学同济医学院法医学系 郑州大学基础医学院法医学教研室 河南省高级人民法院司法技术鉴定处
出处 《郑州大学学报（医学版）》 CAS 北大核心 2007年第2期289-291,共3页 Journal of Zhengzhou University(Medical Sciences)
关键词 河南 汉族 D19S253 D12S391 D18S535 遗传多态性 Henan Han population D19S253 D12S391 D 18S535 genetic polymorphism
分类号 R96 [医药卫生—药理学]
作者简介 赵美乐 男，42岁，博士生，副主任法医师，研究方向：法医物证和法医临床学鉴定
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共引文献3

同被引文献14

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郑州大学学报（医学版）
2007年 第2期

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