摘要
目的 观察应用槐耳颗粒对预防原发性肝癌（HCC）术后复发转移的作用。方法 选择2001年6月至2004年6月可切除的原发性肝癌患者91例，分为治疗组44例和对照组47例；治疗组在术后加用槐耳颗粒冲剂60g／d，共6个月；对照组术后6个月内不用抑癌药物。留取2组患者术前、术后10d及术后6个月外周血，用ELISA和流式细胞学方法检测与HCC复发转移密切相关的血管内皮生长因子（VEGF）和免疫功能指标（T淋巴细胞亚群、NK数值及免疫球蛋白水平），比较2组指标的变化情况。结果 治疗组患者术后6个月血清VEGF值为（361．9±242.5）μg/L，明显低于对照组（463．8±263．3）μg／L（P〈0．05），而且随访期间转移复发率（40．9％）明显低于对照组（61．7％）（P〈0．05）。治疗组血清免疫球蛋白IgA、IgG、IgM值在随访期间的恢复程度好于对照组（P〉0.05），T淋巴细胞亚群CD3、CD4、CD8及NK活性改善则明显高于对照组（均P〈0．05）。治疗组随访（22．7±7．2）个月，对照组（22．9±10.7）个月；治疗组患者累计生存率81.82％（36／44）明显高于对照组63．83％（30／47）。结论 槐耳颗粒冲剂通过改善HCC患者的免疫功能状态和下调患者血清VEGF的表达，可降低HCC术后转移复发率，提高生存率，改善患者的预后。
Objective To observe the clinical effects of Huaier in the prevention of postoperative hepapathocellular carcinoma （ HCC ） recurrence and metastasis. Methods 91 postoperative patients of HCC from June 2001 to June 2004 were randomized into two groups ： treatment group （ group Ⅰ , n = 44 ） and control group （ group Ⅱ, n = 47 ）, After operation, group Ⅰ was treated with Huaier （60 g per day,6 months ） and group Ⅱ was not . The peripheral blood was examined for VEGF and cellular immune marker by the technique of ELISA and flow cytometry in both groups before operation, 10 days after operation and 6 months after operation, Results The level of VEGF in group Ⅰ （ 361.9 ± 242. 5 ）μg/L was lower than that in group Ⅱ （ 463. 8 ± 263.3 ） μg/L （ P 〈 0.05 ）, The recurrence and metastasis rate in group Ⅰ （40.9%）was also lower than those in group Ⅱ （61.7%） （P 〈0. 05 ）, There was no significant difference in increase of IgA,IgG,IgM between group Ⅰ and Ⅱ （ P 〉 0. 05 ）. The level of T cell subsets [CD3,CD4,CD8） and NK in group Ⅰ was higher than that in group Ⅱ （P 〈0.05 for each）. The cumulative survival time of group Ⅰ was （ 22.7 ± 7.2 ） months ,while the survival time of group Ⅱ was （ 22.9 ± 10.7 ） months, The total survival rate of group Ⅰ （81.82% ,36/44） was higher than group Ⅱ （ 63.83% ,30/47 ）. Conclusion Huaier may reduce postoperative HCC recurrence and metastasis rate and improve survival rate by improve the immune function and down-regulating the expressing of VEGF,
出处
《中国综合临床》
北大核心
2007年第3期245-247,共3页
Clinical Medicine of China
关键词
原发性肝癌
槐耳颗粒
血管内皮生长因子
细胞免疫功能
Hepatocellular carcinoma
Huaier
Vascular endothelial growth factor
Cellular immune function
