摘要
目的探讨多脏器功能障碍综合征(MODS)早期发病的免疫功能状态与急性虚证之间的关系及中西医结合治疗对MODS免疫功能的调节作用。方法应用免疫荧光技术,随机对照、动态检测62例MODS急性虚证患者外周血中CD4+辅助性T细胞亚群1/2(Th1/Th2)变化及单核细胞人类白细胞分化抗原DR(HLA-DR)表达的情况,并比较单纯西医治疗与中西医结合治疗对促炎-抗炎平衡的影响。结果MODS急性虚证患者外周血的Th1/Th2比值、单核细胞表面HLA-DR含量低于正常人(P<0.01);中西医结合治疗组两指标高于西医常规治疗组(P<0.05),且28天存活率较西医常规治疗组高(P<0.05),最终死亡率两组差异无显著性意义(P>0.05)。结论MODS发病早期的免疫抑制与急性虚证具相关性;中西医结合治疗能够改善急性虚证患者免疫抑制状态。
Objective To probe into the relationship between immune function at the early stage of multiple organ dysfunction syndrome（MODS） and acute deficiency syndrome,and to evaluate the immunoregulative effects of combined treatment of Chinese medicine and western medicine on MODS. Methods T-cell subgroup1/2（Th1/Th2） and the expression of human leukocyte antigen-DR（HLADR） on monocytes in 62 cases of acute deficiency syndrome of MODS were randomly determined by immunofluorescence technique. Effects of the combined Chinese medicine and western medicine ,and the simple western medicine on the balance of immunity of acute deficiency syndrome were compared. Results In the patient of acute deficiency syndrome of MODS,the Th1/Th2 and HLA2DR in peripheral blood were significantly lower than the healthy controls （P〈0. 01）. Compared with the western medicine group, the levels of Th1/Th2,HLA-DR and the 28-day survival rate were significantly higher in the group of combined treatment of Chinese medicine and western medicine（P〈0. 05）. There was no significant difference in the mortality. Conclusion The immunosuppression at the early stage of MODS is correlated with acute deficiency syndrome ,and combined treatment of Chinese medicine and western medicine can improve immunosuppresion of the patient with acute deficiency syndrome.
出处
《中医杂志》
CSCD
北大核心
2007年第2期163-165,共3页
Journal of Traditional Chinese Medicine
基金
天津市卫生局中西医结合基金项目(02001)
关键词
多器官功能衰竭
虚证
中西医结合疗法
免疫抑制状态
Multiple organ function failure
Deficiency syndrome
Combined treatment of Chinese and western medicine
作者简介
通讯作者：张畔，（022）23626385
