摘要
目的观察以糖足方为主综合治疗糖尿病足(DF)的临床疗效及其对足背动脉血流动力学变化的影响。方法将108例DF患者随机分为糖足方组和西药组各54例,糖足方组给予糖足方治疗,西药组给予654-2治疗,观察两组临床疗效及治疗后足背动脉血流动力学变化。并设35名健康体检者为健康对照组。结果糖足方组溃疡肉芽组织出现时间(GT)、溃疡愈合时间(HT)均短于西药组,愈合率明显高于西药组,截趾(肢)率明显低于西药组,两组间相应指标比较,差异具有显著性意义(P<0.05或P<0.01)。与健康对照组比较,DF患者足背动脉血管内径变小,峰值流速加快,血流量减少,谱宽度增加;治疗后,两组足背动脉血流动力学指标均明显改善(P<0.01),糖足方组改善更显著(P<0.05)。结论以糖足方为主综合治疗DF效果优于以654-2为主的综合疗法。
Objective To study the clinical effect of Diabetic Foot Formula （DFF） and its influence on hemodynamics of arteria dorsalis pedis （ADP）. Methods Totally 108 cases of DF were randomly divided into DFF group and western medicine group,each containing 54 cases. DFF group was treated by DFF, while western medicine group by anisodamine. Clinical effect and hemodynamic change of ADP in both groups were observed before and after treatment. Thirty five healthy persons were selected as healthy control group. Results In comparison with western medicine group,granulation tissue formation time （GT） and ulceration healing time （HT） were shorter,healing rate was higher,amputation rate was lower in DFF group,resulting in significant differences （P〈0.05 or P〈0. 01 ）. In comparison with healthy control group,DF patients had smaller inner diameter of ADP,quicker peak flow rate,lower blood flow,and wider spectral width. After treatment,hemodynamic index of ADP improved in both treatment groups （P〈0.01）,espically in DFF group （P〈0.05）. Conclusion The effect of complex treatment mainly consisting of DDF is superior to that of anisodamine.
出处
《中医杂志》
CSCD
北大核心
2007年第1期35-37,共3页
Journal of Traditional Chinese Medicine
基金
广西自然科学基金资助项目(桂科自0229043)
作者简介
通讯作者：范冠杰，fgjie@tom.com，13925119990
