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丙基硫氧嘧啶致抗ANCA阳性小血管炎5例分析 被引量:5

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摘要 目的:研究丙基硫氧嘧啶(PTU)引起的抗中性粒细胞胞浆抗体(ANCA)阳性小血管炎的临床病理表现及治疗。方法:对我院近年诊治的5例FTU引起的ANCA阳性小血管炎患者进行临床病理分析及治疗效果回顾。结果:5例病人中男1例,女4例;年龄11岁~39岁,平均26岁;服PTU时间3~36个月,4例有肾脏受累,3例肺部受累,其他如血液系统、皮肤、关节肌肉、眼鼻等均可受累。ANCA检测5例均识别MPO,ESR明显增快,CRP增高。肾活检1例新月体肾炎,1例局灶节段肾小球硬化症,1例局灶性坏死性肾小球肾炎。5例患者立即停服PTU,均应用免疫抑制荆,2例咯血合并感染者加用丙种球蛋白。5例患者随访7~43个月,临床症状缓解,ANCA检测阴性。结论:PTU可引起ANCA阳性小血管炎,及时停PTU,并予免疫抑制剂治疗,预后好。
出处 《中国中西医结合肾病杂志》 2007年第2期102-103,共2页 Chinese Journal of Integrated Traditional and Western Nephrology
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参考文献7

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