摘要
中医学是传统的系统生物医学,只有在系统层面上研究传统中医药,才能更为合理地使之得到继承、阐释与发扬。本文阐述了项目组开展的“中医药计算系统生物学”研究内容,发现基于生物网络及其调控,可以较为有效地理解中医证候宏观与微观特征、方剂多靶点整合调节作用等重要问题,表明中医药计算系统生物学可望成为符合中医特色,又与当今科学前沿协调发展的中医药现代研究方法。
Only through the view of the system can one understand the characteristics of traditional Chinese medicine （TCM）, an ancient medical system. Using the approach of computational system biology （ CSB）, author has created a method, named TCMCSB, to understand the methodologies used by TCM. As a novel research method, TCMCSB is designed to shift the strategy of substance - function to the one focusing on relation - function, creating a new path from information integration to systems modeling. Following the roadmap of ＂Interaction→Network→Function＂, a case study is presented here to address the relationship between the Cold ZHENG and Hot ZHENG, and associated herbal formulas, in an effort to demonstrate the appiications of TCMCSB. It is found that one is in a position to interpret the scientific basis of both ZHENG and associated herbal treatments, when the method of TCBCSB is used. Author concludes that TCMCSB is a method suitable for TCM research.
出处
《世界科学技术-中医药现代化》
2007年第1期105-111,共7页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家科技支撑计划项目子课题(2006BAI08B05):中医药计算系统生物学方法及其示范研究
教育部高等学校全国优秀博士学位论文作者专项资金(200366):中药分子组合调节血管增生的理化与生物信息研究
科技部国家十五攻关项目(2004BA721A47):医学发展的前景与趋势研究
关键词
中医药
寒热证候
计算系统生物学
生物信息学
生物网络
traditional Chinese medicine
Cold ZHENG and Hot ZHENG
computational systems biology
bioinformatics
biological network
作者简介
联系人：李梢，医学博士，清华大学生物信息学研究所副教授，清华信息科学与技术国家实验室生物信息学研究部副主任，主要研究方向：中医药生物信息学，中医药计算系统生物学；Tel：010-62797035，E—mail：shaoli@mail.tsinghua.edu．cn。
