摘要
目的 探讨低剂量长春瑞滨（NVB）加顺铂（DDP）联合同步胸部放疗对局部晚期非小细胞肺癌（NSCLC）的疗效与安全性。方法 34例ⅢB期NSCLC患者接受NVB＋DDP联合同步放疗，放疗剂量在加～66Gy之间。结果客观缓解率为56％（19／34）；中位生存期16．5个月，1年生存率62％（21／34），2年生存率35％（12／34）。47％（16／34）患者发生不同程度的放射性食管炎，其中Ⅲ、Ⅳ度食管炎29％（10／34）；Ⅲ、Ⅳ度白细胞减少18％（6／34）；Ⅲ、Ⅳ度血小板减少3％（1／34）。结论 低剂量NVB＋DDP方案化疗联合同步胸部放射治疗对局部晚期NSCLC有效，患者可以耐受。
Objective To investigate efficacy and toxicity of concurrent radiotherapy combining with low-dose vinorelbine plus cisplatin in locally advanced non-small cell lung cancer. Methods Thirty four patients with staged Ⅲ B non-small cell lung cancer were given concurrent thoracic radiotherapy combining with vinorelbine plus cisplatin. Total dose of radiation was from 40 to 66 Gy. Results Objective response rate of 56% （19/34） was achieved with median survival of 16.5 months, 1 year survival rate of 62% （21/34） and 2 year survival rate of 35% （ 12/34 ）. About 47% （16/34） of the patients developed varied degrees of esophagitis. WHO grade 3-4 esophagitis was seen in 29% （10/34） of the cases, grade 3-4 hypoleukemia and thrombocytopenia were seen in 18% （6/34）and 3% （1/34）respectively. Conclusion Concurrent radiotherapy combining with low-dose vinorelbine and cisplatin was effective and tolerable in the management of locally advanced nonsmall cell lung cancer.
出处
《国际肿瘤学杂志》
CAS
2007年第2期147-149,共3页
Journal of International Oncology
关键词
癌
非小细胞肺
放射疗法
药物疗法
Carcinoma,non-small-cell lung
Radiotherapy
Drug therapy
