摘要
目的探讨慢性阻塞性肺疾病(COPD)急性加重期治疗后外周血细胞因子IL-6、IL-8、TNF-α的临床意义。方法选择呼吸科32例COPD急性加重期住院患者,分别于治疗前及10-14 d治疗病情缓解后行血常规检查,肺功能检查,用ELISA法检测血清IL-6、IL-8、TNF-a浓度。结果COPD急性加重期时外周血中性粒细胞占白细胞总数百分比(Neu/Leu%),血清IL-6、IL-8、TNF-a浓度均明显高于治疗后水平(P<0.01),而急性加重期FEV1明显低于治疗后水平(P<0.01)。结论血清IL-6、IL-8、TNF-α升高是COPD急性加重的主要指标。
Objective To investigate clinical value of the serum level of interleukin-6 （ IL-6 ） , interleukin-8 （ IL-8 ） and tumor necrosis factor-α（TNF-α） in patients with acute exacerbation of chronic obstructive pulmonary disease before and after 10 - 14 d therapy. Methods The serum samples were collected and prepared from 32 inpatients with acute exacerbation of chronic obstructive pulmonary disease before and after 10 - 14 days therapy. IL-6, IL-8 and TNF-α in serum was detected by ELISA and blood routine and pulmonary, function were detected in all patients. Results The percentage of peripheral blood neutrophilic granulocyte and serum level of IL - 6, IL - 8 and TNF-α in patients with acute exacerbation of chronic obstructive pulmonary disease before treatment were significantly higher than that after therapy （P 〈0. 01 ）. The FEV1 level of pulmonary, function in patients with acute exacerbation of chronic obstructive pulmonary disease was notable lower than that after therapy （ P 〈 0.01 ）. Conclusion It is indicated that the level of IL-6,IL-8 and TNF-α may be a main marker for acute exacerbation of chronic obstructive pulmonary disease.
出处
《临床肺科杂志》
2007年第3期224-225,共2页
Journal of Clinical Pulmonary Medicine
