摘要
目的观察慢性阻塞性肺疾病（COPD）急性加重期患者和急性加重期缓解患者的血浆白介素17（IL-17）、白介索8（IL-8）及白三烯B4（LTB4）含量变化。同时观察COPD患者血浆IL-17与IL8及LTB4含量的相关性。方法随机抽取COPD急性加重期患者、急性加重期缓解患者各35例，健康对照者15例，采用双抗夹心ELISA法测定三组人群血浆IL-17、IL-8、LTB4含量。结果COPD急性加重期患者血浆IL-17、IL-8及LTB4水平明显高于急性加重期缓解患者和健康对照者，差异有统计学意义（P〈0．05），COPD急性加重期缓解患者血浆IL-17、IL-8及LTB4水平亦明显高于健康对照者，差异有统计学意义（P〈0．05）。COPD急性加重期患者和急性加重期缓解患者血浆ID8、LTB4含量均与IL-17呈正相关。结论IL-17参与了COPD的炎症过程，而与IL-8、LTB4呈正相关。
Objective To investigate the changes of interleukin （IL）-17 in plasma of patients with chronic obstructive pulmonary disease（COPD） both during acute exacerbation and stable stage with and its relationship with interleukin 8 and leukotriene B4 （LTB4）. Methods Blood samples were obtained in patients with COPD both during acute exacerbation and stable stage. Healthy nonsmoking volunteers were included as controls. The concentrations of IL-17,IL-8 and LTB4 in the plasma were measured by enzymelinked immunosorbent assay. Results The concentrations of IL-17,IL-8 and LTB4 in patients with coPD during acute exacerbation were significantly higher than those in patients with COPD during stable stage and in the control subjects （ P〈0.05）. The concentrations of IL-17, IL 8 and LTB4 in patients with COPD during stable stage were significantly higher than those in the control subjects （ P 〈0.05）. The levels of IL- 17 in patients with COPD both during acute exacerbation and stable stage correlated positively with those of IL-8 and LTB4. Conclusion The concentrations of IL-17, IL-8 and LTB4 in patients of COPD were significantly increased. IL-17 may play a role in the airway inflammation of COPD.
出处
《国际呼吸杂志》
2007年第3期171-173,共3页
International Journal of Respiration
作者简介
通讯作者；李廷谦。
