摘要
目的:探讨利用介入治疗联合三维适形放疗(3-DCRT)和调强放疗(IMRT)对中晚期肝癌进行综合治疗的疗效。方法:确诊的中晚期原发性肝癌62例分为2组,A组22例先行动脉化疗栓塞(transcatheter arterial chemoembolization, TACE)治疗后再行3-DCRT(18例)和IMRT(4例),B组40例单纯行TACE治疗。比较两组的近期疗效和毒副反应。结果:A组完全缓解(CR)2例,部分缓解(PR)11例,总有效率(CR+PR)为59．1％;B组CR 0例,PR 13例;(CR+ PR)为32．5％。A组近期疗效优于B组, z=2．258,P=0．023 8。肝脏急性不良反应,A组4例,B组2例,差异无统计学意义,P>0．05。结论:介入治疗联合3-DCRT能提高中晚期肝癌的近期疗效,不增加肝脏急性不良反应。
OBJECTIVE： To evaluate the efficacy of interventional therapy combined with three-dimensional conformal radiation therapy （3-DCRT） or intensity modulated radiation therapy （IMRT） for middle and advanced hepatocellular carcinoma. METHODS： Sixty-two patients with hepatocellular carcinoma were divided into two groups group A and B. Group A consisted of 22 patients, treated with 3-DCRT （18 patients） and IMRT （4 patients） after transcatheter arterial chemoembolization （TACE）. Fourty patients in group B were only given TACE. RESULTS： In group A, two cases showed complete response （CR） and 11 cases showed partial response （PR）. The overall response rate （CR＋PR） in group A was 59.1%. In group B, there were no cases showing CR and 13 cases showing PR. CR＋PR in group B was 32.5%. Better effects were got from group A than that from group B, z=2. 258, P=0. 023 8. For acute adverse effects in the liver, there was no significant difference between group A （3 cases） and group B （2 cases）, P〉0. 05. CONCLUSIONS：Interventional therapy combined with 3-DCRT could improve the effect in the treatment of middle and advanced hepatocellular carcinoma without increasing acute adverse effects in the liver.
出处
《中华肿瘤防治杂志》
CAS
2006年第24期1887-1889,共3页
Chinese Journal of Cancer Prevention and Treatment
基金
广西医疗卫生重点科研课题(重200526)
关键词
肝肿瘤/放射疗法
放射疗法
适形
化学栓塞
治疗性
综合疗法
liver neoplasms/radiotherapy
radiotherapy, conformal
chemvembolization, therapeutic
combined modality therapy
作者简介
【通讯作者简介】冯国生，男，广西博白人，副主任医师，主要从事肿瘤内科的研究工作。Tel：86—771—2186339；E-mail：fengguosheng88988@163．com
