摘要
肝纤维化是肝脏对各种原因所致肝损伤的创伤愈合反应,是组织发生修复反应时细胞外基质(ECM)合成、降解与沉积不平衡而引起的病理过程.肝纤维化的形成涉及多种细胞、细胞因子及ECM的变化.其中肝星状细胞(HSCs)激活并转化为肌成纤维细胞是肝纤维化发生、发展的核心环节,各种致肝纤维化因素均把HSCs作为最终靶细胞,促使其转化为肌成纤维细胞而导致肝纤维化的发生.影响肝纤维化形成的因素很多,至今尚未完全阐明.临床资料表明,免疫抑制对肝纤维化的进程起明显的促进作用,在HCV和HIV联合感染或肝移植需长期应用免疫抑制药物的患者,肝纤维化进程加快.本文就免疫因素在肝纤维化形成过程中的作用的研究进展作一综述.
Hepatic fibrosis is a wound-healing process responsive to a variety of factors, and it is also a pathological change caused by the imbalance of synthesis, degradation and deposition of extracellular matrix （ECM） during tissue repair. The changes of many cells, cytokines and ECM are involved in the formation of liver fibrosis, during which the activation of hepatic stellate cells （HSCs） as well as their transforming into myofibroblasts is the central step. Various agents take HSCs as the final target cells and stimulate them to transform into myofibroblasts. Many factors affect the formation of hepatic cirrhosis, but not every one is illuminated completely. Immune suppression accelerates the process according to clinical data. The process speeds up in patients with co-infection of hepatitis C virus （HCV） and human immunodeficiency virus （HIV） and liver transplantation that needs long-term treatment of immunosuppressive drugs.
出处
《世界华人消化杂志》
CAS
北大核心
2007年第3期205-210,共6页
World Chinese Journal of Digestology
基金
上海市重点学科建设项目
No.Y0205
上海市科学技术委员会基金资助项目
No.054009618~~
作者简介
陆伦根,教授,主任医师,博士生导师,主要从事消化疾病的基础和临床研究工作．通讯作者：陆伦根．上海市，上海交通大学医学院附属仁济医院消化内科 lungenlu1965@yahoo.com.电话：021-633641侣传真：021—63112874
