摘要
目的观察丙戊酸镁缓释剂治疗癫的疗效及其对癫患儿认知功能的影响。方法对38例患儿予丙戊酸镁缓释剂治疗,并密切观察其发作控制的程度、服药期间的不良反应,定期复查肝功能和血常规,治疗前、治疗后6个月分别予患儿智商、P300测定,与正常对照组40例比较。结果完全控制18例(47.4%),显效11例(28.9%),有效6例(15.8%),无效3例(7.9%),总有效率92.1%;治疗前、治疗后6个月癫组智商与正常对照组相比,差异均有显著性(P均<0.01);治疗后6个月癫患儿的P300潜伏期、波幅治疗6个月后较治疗前有所改变,但均无显著性差异(P均>0.05)。结论丙戊酸镁缓释剂治疗儿童癫疗效显著,使用方便,无明确的不良反应,且对儿童认知功能的影响不明显。
Objective To observe the effect of magnesium valproate sustained release tablets on children with epilepsy and its effects on cagnitlve function. Methods Magnesium valproate sustained release tablets were conducted on 38 cases . Close attention was paid to both the degree of paroxysrn control and side effects during treatment while periodic examinations on liver function and blood routine were also conducted. The intelligence and P300 of children with epileptics were respectively measured before and after 6 - month treatment. Forty children of control group was set up. Results Eighteen cases were totally under controlled （47.4 % ）, 11 obviously effect （28.9 % ）, 6 effect （ 15.8 % ）. The total effective rate in total was 92.1%. Obvious differencees in intelligence between children with epileptics and con trol group before and after 6- month treatment were observed（all P 〈 0.01 ）. The P300 latent period of children with epileptics, though no obvious difference , changed a little after 6- month amplitude treatment（all P 〉 0.05 ）. Conclusions Magnesimn valproate sustained release tablets is a new type of broad- spectrum anti - epileptic drug, which has an obvious effect ontreatment of children with epileptic without anv ohvious adverse reaction. It imposes little influence on children＇s coanitive function.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2006年第24期1730-1731,共2页
Journal of Applied Clinical Pediatrics
关键词
癫痈
儿童
丙戊酸镬缓释剂
认知功能
epileptic
child
magnesium valproate sustained release tablets
cognitive function
作者简介
何艳，女，副主任医师，硕士学位，研究方向为情绪障碍和行为问题。
