摘要
目的探讨男性更年期综合征的临床特点。方法选择符合临床诊断标准的男性更年期综合征患者,详细分析其一般特征、临床症状评分、生殖内分泌激素测定,并进行补充雄激素、综合治疗4周及疗效观察。结果睾酮平均水平(396．7±128．6)ng／dl,其中<275ng／dl(10nmol／L)者27例(24．1％),275～375ng／dl者29例(25．9％),>375ng／dl(13nmol／L)者56例(50％)。具有完整治疗随访结果的患者共73例,其中对睾酮水平<375ng／dl者进行雄激素补充(安特尔120mg／d)及综合治疗的患者共39例,临床症状改善有效率87．2％;对睾酮水平≥375ng／dl者,仅单纯进行支持和对症治疗的共34例,临床症状改善有效率67．6％,两组疗效差异有统计学意义(P<0．05)。结论男性更年期综合征病因多样,雄激素部分缺乏是重要原因,补充雄激素及综合治疗可显著改善雄激素水平低下患者的症状,疗效优于雄激素水平正常者的单纯综合治疗。
Objective To explore clinical characteristics of male climacteric syndrome. Methods 112 patients who could fulfill the clinical diagnosis of male climacteric syndrome were selected, common features were recorded, clinical climacteric symptoms were evaluated and scored, reproductive hormones were detected. Testosterone supplement therapy and combined therapy was given for 4 weeks and the effect was observed. Results The average level of testosterone was （396.7± 128.6）ng/dl, with 27 cases （24.1%） less than 275ng/dl （10 nmol/L）, 29 cases （25.9%） between （275±375）ng/dl, and 56 cases over 3±75 ng/dl （13 nmol/L）. Totally 73 patients received treatment and following up. 39 cases with lower testosterone （〈375ng/dl） were treated with testosterone supplement therapy（TST） （ andriol 120 mg/day ） and combined treatment, clinical improvement rate of male climacteric symptom reached 87.2%; 34 cases with normal testosterone （≥375ng/dl） accepted only combined treatment, clinical ：improvement rate was 67.6%, and statistic significant existed between the two group, P〈0.05. Conclusion Patients with male climacteric syndrome may have versatile etiology, combined therapy can improve clinical symptom significantly. Partial androgen deficiency is the important reason and TST is more effetive.
出处
《中国男科学杂志》
CAS
CSCD
2006年第12期39-42,共4页
Chinese Journal of Andrology
关键词
男性更年期综合征
雄激素
诊断
治疗
male climacteric syndrome
, androgen
diagnosis
therapy
