摘要
c-myc基因在许多肿瘤的发生、发展过程中起着重要作用,它主要通过对靶基因的转录调控发挥作用。对c-myc如何调节肿瘤细胞周期生长抑制基因转录机制进行综述。c-myc对细胞周期的调控主要通过对生长抑制基因转录抑制实现,主要有2个不同机制一个通过myc/Max二聚体中c-myc蛋白的羧基端(C末端)与Mil-1形成复合物与生长抑制基因p15等启动子Inr区域结合,拮抗其他转录激活因子如Mil-1与Inr结构结合。另一机制c-myc及可能存在的抑制物与转录激活因子Sp1及SMad(smaandmadhomologue)等形成复合物干扰Sp1等对生长抑制基因的激活。造成细胞恶性转化及增殖。
Expression of oncogene c-myc results in oncogenic activation and contributes to progression of a wide range of tumors, myc executes its multiple activities mostly through transcriptional regulation of the target genes. This paper reviews the mechanism of growth arrest gene transcription repression of cell cycle inhibitors by myc. It appears that myc repress growth arrest gene transcription by at lest two distinct mechanisms. One mechanism is limited to the binding of myc/Max heterodimers to the Inr element in their promoters and inhibition of Mil-1 or other transcriptional activator via the C-terminal domain of c-myc. The other mechanism is dependent on c-myc bingding to the Spl/SMad transcription factor via the c-myc repressed by c-myc and what other modes of c-myc transcriptional repression may exist. The ability of c-myc to repress transcription of growth arrest genes may contribute to its potential to promote proliferation and oncogenesis.
出处
《中华肿瘤防治杂志》
CAS
2006年第22期1752-1754,共3页
Chinese Journal of Cancer Prevention and Treatment
作者简介
陈龙，男，四川射洪人，硕士，主要从事肿瘤临床的研究工作。现兰州军区总医院肿瘤科工作。Tel：86—931—8975260 E—mail：brightdot88@sohu．com
【通讯作者】陈洁平，女，贵州贵阳人，博士，副教授，硕士生导师，主要从事血液肿瘤临床的研究工作。E-mail：chenjpxn@yahoo．com．cn
