摘要
年轻乳腺癌(≤35岁)发病率呈上升趋势,一般认为与年老乳腺癌相比更具侵袭性,预后差。占同期乳腺癌的5%～13%,主要发病危险因素是乳腺癌家族史阳性,并较多具有BRCA1/2基因突变。由于腺体致密,早期诊断存在一定困难。其具有更多不利的病理学及生物学特征。治疗上应重视全身综合治疗。本文就年轻乳腺癌的发病情况、危险因素、临床诊断、形态学及生物学特征、治疗等方面作一综述,以期早期发现及改善生存率。
The Incidence rate for young patients （≤35 years） is gradually increased. It is widely believed that young patients have a worse prognosis than the older. The patients with the age of less than 35 account for 5%-13% of the cases diagnosed, whose main rask factors include a family history of breast cancer and more frequent BRCA1/2 mutations. The early diagnosis for the young breast-cancer population is difficult because of the pycnotic glandular organs. It is useful to improve early diagnosis rate and survivals by reviewing its prevalence, risk factor, clinical diagnosis, pathological and biological features and therapeutic regimen.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2006年第22期1316-1320,共5页
Chinese Journal of Clinical Oncology
关键词
年轻乳腺癌
临床研究
Young patient Breast cancer Clinical analysis
作者简介
通讯作者：孟洁
