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血管内皮依赖性超极化因子的研究进展 被引量:6

Recent advances in study of endothelium-dependent hyperpolarizing factor
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摘要 内皮依赖性超极化因子(endothelium-depen-denthyperpolarizingfactor,EDHF)是血管平滑肌内皮源性舒张反应中通过非环氧合酶、非一氧化氮合酶途径的舒张因子。在不同物种、不同血管,EDHF反应都得到了确认。其在心血管生理学和药理学方面有着重要的作用。 Besides cyclooxygenase and nitric oxide synthase, another distinct endothelial pathway, endotheliurn-dependent hyperpolarization factor (EDHF), is involved in relaxation of the vascular smooth muscle cells. EDHF has been demonstrated unequivocally in various blood vessels from different species, including human, and is likely to play an important role in cardiovascular physiology and pharmacology.
出处 《中国临床药理学与治疗学》 CAS CSCD 2006年第10期1087-1091,共5页 Chinese Journal of Clinical Pharmacology and Therapeutics
基金 安徽省人才专项基金资助(№2005z031) 安徽医科大学基金资助(№2005KJ07)
关键词 内皮依赖性超极化因子 血管舒张 K^+通道 endothelium-dependent hyperpolarization factor vasodilatation potassium channels
作者简介 范一菲,女,讲师,硕士研究生,研究方向:心血管药理学。Tel:0551-3642299 E-mail:fanyifei100@yahoo.com.cn 陈志武,男,博士生导师,研究方向:心脑血管药理学.Tel:0551-5161133 E-mail:wzcxiong@mail.hf.ah.cn
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  • 1Tanaka Y,Koike K,Toro L.MaxiK channel roles in blood vessel relaxations induced by endothelium-derived relaxing factors and their molecular mechanisms[J].J Smooth Muscle Res,2004; 40:125-53
  • 2Feletou M,Vanhoutte PM.Endothelium-dependent hyperpolarizationof canine coronary smooth muscle[J].Br J Pharmacol,1988 ;93:515-4
  • 3Chen G,Suzuki H,Weston AH.Acetylcholine releases endothelium-derived hyperpolarizing factor and EDRF from ratblood vessels[J].Br J Pharmacol,1988; 95:1165-74
  • 4Matoba T,Shimokawa H,Nakashima M,Hirakawa Y,Mukai Y,Hirano K,et al.Hydrogen peroxide is an endothelium-derived hyperpolarizing factor inmice[J].J Clin Invest,2000; 106:1521-30
  • 5Rosolowsky M,Campbell WB.Role of PGI2 and EETs in the relaxation of bovine coronary arteries to arachidonic acid[J].Am J Physiol Heart CircPhysiol,1993;264:327-35
  • 6Rosolowsky M,Campbell WB.Synthesis of hydroxyeicosatetraenoic acids (HETEs) and epoxyeicosatrienoic acids (EETs)by cultured bovine coronary artery endothelial cells[J].Biochim Biophys Acta,1996; 1299:267-77
  • 7Singer HA,Saye JA,Peach MJ.Effects of cytochrome P450 inhibitors on endothelium-dependent relaxation in rabbit aorta[J].Blood Vessels,1984;21:223-30
  • 8Halcox JPJ,Narayanan S,Crames-Joyce L,Mincemoyer R,Quyyumi AA.Characterization of endothelium-derived hyperpolarizing factor in the human forearm microcirculation[J].Am J Physiol Heart Circ Physiol,2001 ;280:2470-7
  • 9Zhang Y,Ottman CL,Lu T,Lee HC,Dellsperger KC,VanRollins M.EET homologs potently dilate coronary microvessels and activate large conductance Ca2 + -activated potassium channels[J].Am J Physiol Heart Circ Physiol,2001 ;280:2430-40
  • 10Hecker M,Bara AT,Bauersachs J,Busse R.Characterization of endothelium-derived hyperpolarizing factor as a cytochrome P450-derived arachidonic acid metabolite in mammals[J].J Physiol,1994;481:407-14

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