摘要
目的研究牛蒡子苷对血瘀大鼠血液流变学和血栓凝血因子的影响。方法测定口服不同剂量的牛蒡子苷后对血瘀证大鼠流变学、F ib、aPTT和PT的影响。结果牛蒡子苷可以明显降低急性血瘀大鼠全血黏度,红细胞聚集指数,红细胞刚性指数和还原黏度,明显延长血瘀大鼠PT和aPTT时间,降低F ib浓度。结论牛蒡子苷能显著改善血瘀证大鼠血液流变学和抗凝血作用。
OBJECTIVE To study influence of arctiin from seeds of Arctium lappa on hemotheology of experimental rats with the blood stasis syndrone. METHODS The blood hemorheclogy parameters, Fib, aPTT and PT of experimental rats with the blood stasis syndrone were evaluated using semi-automatic biochemical analysis. RESULTS Arctiin obviously decreased their high shear, middle shear, low shear, the blood viscosity, red blood cell aggregation index, red blood cell rigidity index and reduetive viscosity. It also significantly prolonged the time of aPTT and PT and lowed the Fib concentration. CONCLUSION Arctiin apparently ameliorated the blood theology abnormality and enhanced anti-coagulation effect on experimental rats with the blood stasis.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2006年第6期443-446,共4页
Chinese Journal of Modern Applied Pharmacy
关键词
牛蒡
牛蒡子苷
血液流变学
抗凝作用
Arctium lappa L
arctiin
hemorheology
anti-coagulation
作者简介
通讯作者：郑一敏，重庆工学院生物工程学院，400050，Tel：023-68662335
