摘要
研究环氧合酶(COX-2)在慢性肝炎、肝硬化组织中蛋白表达情况,并结合临床进行评价。采用免疫组化法,研究慢性肝炎33例,肝炎肝硬化17例组织中COX-2的蛋白表达。COX-2与慢性肝炎病情轻重有关,随肝脏炎症程度的加重,COX-2表达相应增加(P＜0．05)；COX-2在活动性肝硬化要显著高于静止性肝硬化,(P＜0．05)。COX-2的过度表达,可能参与了肝脏的炎症过程。对肝纤维化、肝硬化的发生、发展无直接的始动和促进作用。
To study the expression of eyelooxygenase -2 （COX -2） in liver tissues with chronic hepatitis or cirrhosis. The expression of COX - 2 in 33 eases with chronic hepatitis and 17 eases with liver cirrhosis was detected by immunohistoehemistry. With the degree of liver inflammation inereasing, the expression of COX - 2 signifieantly inereased （ P 〈 0. 05 ）. Its expression in patients with active cirrhosis was obviously higher than that in patients with quieseenee eirrhosis （P 〈 0. 05 ）. The result shows that COX -2 may involve in hepatic inflammatory and fibrosis.
出处
《临床肝胆病杂志》
CAS
2006年第6期422-424,共3页
Journal of Clinical Hepatology
基金
南通市科技局资助(市S2025)
关键词
环氧合酶-2
免疫组化
慢性肝炎
肝硬化
eyelooxygenase - 2
immunohistoehemistry
ehronie hepatitis
eirrhosis
作者简介
邵建国（1965-），男，江苏省南通市人，博士研究生，副主任医师，从事消化科专业。
