摘要
目的比较开胸术后患者自控静脉镇痛(PCIA)中氟比洛芬酯联合芬太尼与单纯芬太尼的镇痛效果与不良反应。方法选择开胸手术术后行PCIA患者60例,随机均分为两组。芬太尼组术后镇痛给予芬太尼1·25mg+昂丹司琼8mg/100ml;氟芬组关胸前给予氟比洛芬酯50mg,术后镇痛给予芬太尼0·5mg+氟比洛芬酯200mg+昂丹司琼8mg/100ml。两组PCIA泵的设置,维持量2ml/h,单次负荷剂量0·5ml,锁定时间15min。观察两组术后24、48h的镇痛、镇静评分和不良反应发生率,并于镇痛治疗前后采用Sonoclot凝血与血小板功能分析仪评定两组患者的凝血功能。结果两组术后镇痛及镇静评分差异无显著意义。氟芬组药物不良反应发生率低于芬太尼组。两组间镇痛治疗后凝血功能变化差异无显著意义。结论氟比洛芬酯联合芬太尼用于开胸术后PCIA的镇痛效果与单纯芬太尼相似,但不良反应明显降低,对凝血与血小板功能无明显影响。
Objective To access the analgesia effect and side effects of and flurbiprofen axetil combined with fentanyl. Methods Sixty patients underwent thoracic surgery were randomly divided into two groups equally with 30 cases each. Group A was given fentanyl 1.25 mg plus ondansetron 8 mg diluted to 100 ml via PCIA after surgery. Group B was administrated flurbiprofen axetil 50 mg before thorax closure and fentanyl 0.5 rag,and flurbiprofen axetil 200 mg plus ondansetron 8 mg diluted 100 ml was adminitrated via PCIA after surgery. The PCIA rate was 2 ml/h, blous 0.5 ml, lock time 15 min. Analgesia and sedation grade were accessed and side effects were recorded. Coagulation and platelet function were evaluated using Sonoclot analyzer. Results There were no significant differences in analgesia and sedation grade between two groups. The side effects were lower in group B than those in group A. There were also no significant difference in coagulation and platelet function between two groups. Conclusion Flurbiprofen axetil combined with fentanyl can obtain similar analgesia and sedation effects to fentanyl alone, but can reduce side effects. PCIA with flurbiprofen axetil has no significant effect on coagulation and platelet function.
出处
《临床麻醉学杂志》
CAS
CSCD
2006年第11期836-838,共3页
Journal of Clinical Anesthesiology
基金
上海市交通大学附属胸科医院科研基金资助(YE04-03)
作者简介
责任作者
