摘要
目的阐述唑烷酮类抗菌药物的最新研究进展。方法根据近期关于新的唑烷酮类抗菌药物研究开发现状的29篇相关文献,对唑烷酮的3位芳基和5位侧链的结构改造特点进行整理和归纳。结果与结论大多数化合物具有提高的抗G+菌活性,部分化合物显示出抗G-菌的活性。另外,还介绍了一类具有扩大的抗菌谱的唑烷酮与其他类型抗菌药物形成的拼合化合物。
Objective To review the recent developments in the research of oxazolidinone antibacterial drugs. Methods The structure modifications on 3-aryl groups and the side-chains of the oxazolidinone ring were summarized on the basis of published literature for oxazolidinones. Results and Conclusions Most compounds could improve antibacterial activities against G^＋ bacteria and some of them exhibited the activities against G^- bacteria. A series of oxazolidinone derivatives that hybridized with other classes of antibiotics, which showed the broad-spectrum antibacterial activities, were reviewed in the paper.
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2006年第11期739-744,共6页
Journal of Shenyang Pharmaceutical University
关键词
噁唑烷酮类化合物
抗菌药物
构效关系
oxazolidinones
antibacterials
structure-activity relationships（SAR）
作者简介
翟鑫（1978-），女（汉族），黑龙江哈尔滨人。博士研究生
宫平（1964-），男（汉族），新疆乌鲁木齐人，教授，博士生导师，从事药物化学研究，Tel．024—23882925，E—mail gongpinggp@126．com。
