摘要
近年来,越来越多的研究表明CD4+CD25+调节性T细胞在免疫耐受的过程中起着非常重要的作用。IL-2作为一种T细胞生长因子调控着调节性T细胞诱导免疫耐受的过程。IL-2维持着中枢及外周的调节性T细胞的活性,但是对胸腺调节性T细胞的发育是非必要的。同时,IL-2信号影响着调节性T细胞的功能并维持其竞争适应性。因此,CD4+CD25+调节性T细胞通过与IL-2之间形成的免疫网络调控着免疫耐受的过程,从而影响着机体的免疫平衡。
More and more research proved that CD4^＋CD25^＋ regulatory T cells （Treg cells ） play an important role in immune tolerance in these years. Known as a T cell growth factor, Interleukin-2 （IL-2） regulated the immune tolerance induced by Treg cells. IL-2 sustained the activity of Treg cells both in thymus and periphery while it was dispensable for the development of Treg cells in thymus. In addition, IL-2 signal affected the function of Treg cells and maintained their competitive fitness. Therefore, CD4^＋CD25^＋ Treg cells and IL-2 formed an immune network to regulate the processes of immune response, immune tolerance and autoimmune homeostasis.
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2006年第11期66-69,共4页
China Biotechnology
基金
中国科学院引进海外杰出人才百人计划资助项目(2003-85
Y.Z.)
国家杰出青年基金项目(C03020504
Y.Z.)
作者简介
通讯作者，电子信箱：zhaoy@ioz．ac．cn
