摘要
目的探讨活血化瘀中药三七总皂苷超早期治疗大鼠出血性中风的疗效。方法采用胶原酶法制备高血压脑出血模型。60只大鼠随机分为5组(假手术组、模型组及三七总皂苷高、中、低剂量组),每组12只;造模后4h开始每12h腹腔注射药物或生理盐水1次,共5次。于造模后24h、72h,各组大鼠测脑组织含水量,钠离子、钾离子含量,脑内血肿直径。结果三七总皂苷治疗各组大鼠的神经缺损症状加重(P<0.05),出血侧皮质及基底节脑水含量及钠离子含量较模型组均增加(P<0.05),钾离子含量较模型组减低(P<0.05);三七总皂苷各组治疗后血肿直径较脑出血模型组变小(P均<0.05)。结论三七总皂苷超早期治疗大量脑出血,可加剧早期脑水肿,引起大鼠神经功能缺损计分增加,但有利于加速治疗后血肿的吸收。大量脑出血超早期应用三七总皂苷治疗应慎重。
Objective To study the effect of panax notoginseng saponins （PNS） in treating hemorrhagic apoplexy at super-early stage in rats. Methods Rat model of hypertension with cerebral hemorrhage was induced by collagenase method. Sixty rats were randomly divided into 5 groups： the sham operated group, model group, PNS high, middle, and low dose group, 12 in each; 4 h after modeling, PNS or normal saline was intraperitoneally injected into the rats every 12 h, the total is 5 times. Contents of water, sodium and potassium ion in brain, and the diameter of hematoma in rats of different groups were measured 24 h and 72 h after modeling. Results Compared with the model rats, nerve defect symptoms aggravated, the contents of water and sodium ion in ipsilateral cortex and basal ganglia were significantly higher, the content of potassium ion was lower and the hematoma diameter was obviously less in the PNS-treated rats （all P 〈 0.05）. Conclusion PNS may worsen the brain edema and increase the nerve defect score when it was applied at the early stage of cerebral hemorrhage, but could promote the absorption of hematoma, indicating PNS should be used cautiously in treating patients with large amount of cerebral hemorrhage at super-early stage.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2006年第10期922-925,共4页
Chinese Journal of Integrated Traditional and Western Medicine
基金
湖南省中医药管理局基金重点项目(No.204005)
中国博士后基金资助项目(No.2001)
关键词
脑出血
脑水肿
大鼠
三七总皂苷
cerebral hemorrhage
brain edema
rat
panax notoginseng saponins
作者简介
通讯作者：聂亚雄，Tel：0734—8279061，E—mail：yaxiongnie@yaboo．com
