摘要
目的:探讨颈动脉粥样硬化(CA S)与冠状动脉粥样硬化(CAA S)的影响因素及二者的关系。方法:202例患者根据冠状动脉造影结果分为非冠心病组(NCHD组,54例,冠状动脉直径狭窄<50%);冠心病组(CHD组,148例,至少一支冠状动脉直径狭窄≥50%)。冠心病组又按其血管病变支数分为三个亚组:单支病变组(30例)、双支病变组(42例)、多支病变组(76例)。采用颈动脉超声检测双侧颈总动脉内-中膜厚度、斑块,与冠状动脉造影结果进行对比研究,比较各组之间二者的关系,分析CA S与CAA S的影响因素。结果:①高血压、低密度脂蛋白与冠状动脉病变支数呈正相关(P<0.05),低密度脂蛋白与颈动脉病变分级呈正相关(P<0.05);②与NCHD组比较,CHD组患者颈动脉内膜增厚率和斑块形成率增高(P<0.05);CHD组各亚组之间比较,多支病变组患者颈动脉斑块形成率、多发斑块发生率高于单支组和双支组(P均<0.05);③颈动脉粥样斑块中软斑和混合斑比例:CHD组的高于NCHD组的(P<0.05);CHD组中多支组高于单支组和双支组(P<0.05);④CAA S的冠状动脉病变积分(CSS)与CA S的颈动脉粥样硬化积分(A S)呈正相关(r=0.61,P<0.05)。结论:①高血压、低密度脂蛋白是动脉粥样硬化的危险因素;②冠状动脉粥样硬化和颈动脉粥样硬化密切相关;③CHD组患者颈动脉动脉硬化病变甚于NCHD组患者;而CHD多支病变组患者的又甚于单支病变组和双支病变组。
Objective ： To explore the correlation between carotid atherosclerosis （CAS） and coronary artery atherosclerosis （CAAS）, and their influence factor. Methods ： A total of 202 patients underwent a selective coronary angiography were divided into no coronary heart disease group （NCHD group, 54 cases, 〈50% diameter narrowing） and coronary heart disease group （CHD group, 148 cases, 〉50%diameter narrowing）. CHD patients were divided into three groups according to the coronary branches involved： Group Ⅰ （one branch, 30 cases）. Group Ⅱ （two branches, 42 cases）, Group Ⅲ （multi branches, 76 cases）. The intima-media thickness （IMT） and plaques of common carotid arteries were measured in all patients with ultrasound. Results： 1. Hypertension, LDL-C were positively related to the branches of involved coronary stenosis （P〈0. 05）, LDL-C was positively related to CAS （P〈：0. 05） ; 2.The incidences of increased IMT and plaque were higher statistically in group CHD than those in NCHD group （P〈0. 05）, the incidences of plaque and multi plaque were higher statistically in group Ⅲ than those in group I and Ⅱ （P〈0. 05） ; 3. The ratios of soft plaque and mix plaque of carotid artery were higher statistically in group CHD than those in NCHD group （P〈0. 05）, in group Ⅲ than those in group Ⅰ and Ⅱ （P〈0. 05）; 4. Scores of CAS was positively related to coronary severity scores （CSS） （P〈0. 05）. Conclusion： 1.Hypertension and LDL-C are the rickfactors of coronary arteriosclerosis and the LDL-C is the risk factor of carotid arteriosclerosis;2. Coronary arteriosclerosis is close related with carotid arteriosclerosis, the lesion of carotid arteriosclerosis in CHD patients is more than that of no CHD patients, and of multi branches group is more than one and two branches group in CHD group.
出处
《心血管康复医学杂志》
CAS
2006年第5期441-445,共5页
Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词
颈动脉狭窄
冠状动脉硬化
冠心病
Carotid artery stenosis
Coronary arteriosclerosis
Coronary artery disease
