摘要
目的评价由顺铂(DDP)+5-氟尿嘧啶(5-Fu)组成的PF方案化疗联合放疗治疗中晚期鼻咽癌的疗效和毒副反应。方法84例Ⅲ,Ⅳ期鼻咽癌患者随机分为两组,放化疗组在放疗前、放疗开始后3周及放疗结束后均用PF方案各化疗1疗程,两组放疗方法相同,鼻咽部剂量为65～70Gy/6.5～7周,颈淋巴结转移灶剂量为65～70Gy/6.5～7周。结果放化疗组及单放组治疗结束后3个月鼻咽部肿瘤完全消退率分别为92.6%,85.7%(P>0.05),颈淋巴结转移灶完全消退率分别为88.1%,64.3%(P<0.05)。毒性分析表明,放化疗组毒性反应较单放组高。结论PF方案联合放疗可显著提高中晚期鼻咽癌患者的近期疗效,但加用化疗同时也增加了毒性。
Objective To appraise the 5-year survival rate and the poisonous side reaction of PDD＋ 5-Fu （PF） regimen chemotherapy plus radiotherapy for treating phase Ⅲ, Ⅳ nasophawngeal cancer. Methods 84 cases of phase Ⅲ, Ⅳ nasophawngeal cancer were divided into two groups randomly. PF regimen were used in the chemo-radiotherapy group before, 3 weeks after and after the end of radiotherapy, one course in each interval. The radiotherapeutic methods were the same in the two groups. The dosage both in the nasophawngeal part and the metastatic cervical lymphnodes were 65-70 Gy/6.5-7 weeks. Results 3 months after the end of the treatment, the complete retrogression rates of nasophawngeal cancer were 92.6 % and 85.7 % respectively（P 〉 0.05）, and of metastatic cervical lymphnodes were 88.1% and 64.3 % respectively （P 〈 0.05） in the chemo-radiotherapy group and radiotherapy alone group. Conclusions PF regimen plus radiotherapy can significantly improve the survival rate of middle to advanced nasopharyngeal cancer patients, but the adding of chemotherapy increased the toxicity at the same time.
出处
《肿瘤研究与临床》
CAS
2006年第10期676-677,共2页
Cancer Research and Clinic
作者简介
朱其勇，男，本科，主治医师。
