摘要
目的探讨血清心肌肌钙蛋白I(cardic troponin I,cTnl)水平与心功能、左室射血数(LVEF)及血清肌酐(Cr)之间的关系。方法对118例CHF患者采用发光免疫方法检测血清cTnl含量,根据血清cTnl水平分为两组,同时选20名无心、脑、肾疾病住院患者为对照组。所选患者都进行心功能检查,LVEF及血清Cr测定。结果CHF患者血清cTnl含量明显高于对照组(P<0.05);心功能Ⅳ、Ⅲ、Ⅱ级患者之间血清cTnl比较有显著性差异(P<0.05);CHF组血清Cr水平明显高于对照组(P<0.05),且血清cTnl升高组血清Cr水平与血清cTnl正常组比较有极显著差异(P<0.01)。血清cTnl含量与血清Cr水平呈正相关(r=0.172,P<0.05);而血清cTnl升高组LVEF与血清cTnl正常组比较无显著差异(P>0.05);在cTnl升高组中,缺血性与非缺血性心脏病之间病因比较无显著差异(P>0.05)。结论CHF患者cTnl含量与心力衰竭的程度平行,与肾功能损害有关,但与病因及LVEF无关,可作为心力衰竭诊断、预后判断的辅助指标。
Objective To measure serurn cardiac troponin I （cTn I） level and investiqate its relationship with cardiac function, left ventrieular ejection fracfion（LVEF） and serum creatinine （Cr） in patients with chronic congestive heart failure （CHF）. Methods Study included 118 eases with CHF and 20 eases with no cardiac, cerebral or renal disease as control. All subjects had been detected LVEF, serum cTn I and serum Cr concentrations. According to eTn I level （normal range is 0-0.15ng/ml）, 118 patients with CHF were divided into two groups, eTn I-positive with serum eTn I≥0.15ng/ml （n= 52） and eTn I-negative with serum eTn I 〈 0.15ng/ml （n = 66）. The relationship between serum eTn I and cardiac function and LVEF and serum Cr were analyzed in these two groups. Results Serum eTn I level in patients with CHF was significantly higher than that in the control （ P 〈 0.05）. Similar finding was found in all patients with CHF among cardiac function NYHA Ⅱ, NYHA Ⅲ and NYHAⅣ （ P 〈 0.05）. Higher Cr level was found in patients with CHF than in the control （ P 〈 0.05 ）. Cr concentration in cTn I-positive group was higher than in eTn I -negative group （ P 〈 0.01 ）. Significant positive correlation was found beween cTn I concentration and Cr level in CHF group （r= 0.172, P 〈 0.05）. But there was no significant difference on LVEF between the groups of cTn I-positive and cTn I-negative （P〉0.05）. There was no significant difference about etiological diagnosis between ischenfia and non-isehemia in the eTn I-positive group （ P 〉 0.05）. Conclusions Serum eTn I concentration was parallel increased with CHF severity and renal injury in all patients with CHF, but not related to the cause or LVEF. Therefore, it is of great value as assisted predictors for their diagnosis and prognostic evaluation.
出处
《心脑血管病防治》
2006年第5期284-286,共3页
CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT
关键词
肌钙蛋白I
心功能
左室射血分数
血清肌酐
充血性心力衰竭
Cardiac troponin I
Cardiac function
Left ventricular ejection fraction
Serum creatinine Congestive heartfailure
