摘要
目的探讨强直性脊柱炎(AS)患者血清基质金属蛋白酶-3(MMP-3)和白细胞介素15(IL-15)水平的临床意义。方法采用双抗体夹心ELISA测定45例AS患者和31例健康对照的血清MMP-3、IL-15、肿瘤坏死因子α(TNF-α)及C反应蛋白(CRP)水平,并分析AS患者各指标间的相关性。结果血清MMP-3、TNF-α、CRP水平AS患者显著高于健康对照组(P<0.001),IL-15水平两组比较也有显著性差异(P<0.01);在AS组仅有MMP-3与IL-15之间存在相关性。结论MMP-3和IL-15在AS发病机制中可能起重要作用,可以作为评估AS病情的有价值的血清学指标。
Objective To investigate the significance of MMP-3 and IL-15 in the patients with ankylosing spondylitis （AS）. Methods The serum levels of MMP-3 ,IL-15 ,TNF-α and CRP of 45 patients with AS and 31 healthy controls were tested by sandwich ELISA. The results between the 2 groups were compared each other. Results Significantly increased serum levels of MMP-3 ,TNF-α and CRP were found in AS patients as compared to those in healthy controls（ P 〈 0. 001 ）. The serum level of IL-15 was also significantly higher than that in healthy controls（ P 〈 0.05 ）. only The level of MMP-3 correlated with the level of IL-15 in AS patients. Conclusion MMP-3 and IL-15 might play a certain role for occurrence of AS and become potentially useful serum markers for evaluation of AS activity.
出处
《临床检验杂志》
CAS
CSCD
北大核心
2006年第5期369-370,共2页
Chinese Journal of Clinical Laboratory Science
作者简介
林宁，1969年生，男，副主任技师，主要从事自身免疫病实验诊断研究。
