摘要
采用水蒸气蒸馏和超临界CO2提取与气-质联用技术对厚朴药材中的化学成分进行了研究。结果表明超临界CO2提取的厚朴化学成分比用水蒸气蒸馏的化学成分少,而厚朴酚与和厚朴酚的相对含量却较高。超临界CO2提取的主要成分为新木脂素类化合物如厚朴酚与和厚朴酚;而水蒸气蒸馏的主要成分为倍半萜和氧化倍半萜类化合物如α-桉醇、十氢-α,,α4 a-三甲基-8-亚甲基-2-萘甲醇。水蒸气蒸馏和超临界CO2提取物中均含有咕吧烯、石竹烯、桉叶二烯、α-依兰油烯、1,2,3,5,6,8 a-六氢-4,7-二甲基-1-异丙基萘、1,2,3,4,4A,5,6,8 a-八氢-8-四甲基-2-羟甲基萘。除文献已报道的化合物外,一些化合物如桉叶二烯、1,2,3,5,6,8 a-六氢-4,7-二甲基-1-异丙基萘、α-白檀油烯醇、4-亚甲基-1-甲基-2-(2-甲基-1-丙烯)-1-乙烯基-环庚烷、4,5,6,6 a-四氢-2(1H)-并环戊二烯酮、十氢-α,,α4 a-三甲基-8-亚甲基-2-萘甲醇,β-人参烯和苍术醇也被鉴定出来。
Chemical constituents of extracts from Magnolia officinalis Rehd. et Wils. bark were studied through steam distillation, supercritical CO2extraction and GC-MS technology. The study revealed that chemical components by supercritical CO2extraction possessed less chemical constituents but higher relative contents of magnolol and honokiol than those by steam distillation. Components from M. officinalis by supercritical CO2 extraction mainly contained neolignans such as magnolol and honokiol. However, components by steam distillation were mainly sesquiterpenes and oxygenated sesquiterpenes such as a-eudesmol, decahydro-α, α-, 4α-trimethyl-8-methylene-2-naphthalene-methanol. Substances by steam distillation and supercritical CO2 extraction have the common components such as copanen, caryophyllene, eudesma-4（14）,11-diene, α-muurolene, 1,2,3,5,6,8α-hexahydro-4,7- dimethyl-1-（ 1-methylethyl ） -naphthalene and 1,2, 3,4,4A, 5,6, 8α-octahydro-8-tetramethyl-2-naphthalene-methanol. Except those compounds that have been reported, some compounds such as eudesma-4（14）, 11-diene, 1,2,3,5,6,8α-hexahydro-4,7- dimethyl-1-（ 1-methylethyl ）-naphthalene, α-santalol, 4-methylene-1-methyl-2-（ 2-methyl-1-propen-1-yl ） -1-vinyl-cycloheptane, 4,5,6,6a-tetrahydro-2（1H）-pentalenone, decahydro-a,a,4α-trimethyl-8-methylene-2-naphthalenemethanol, β-panasinsene and hinesol were identified.
出处
《林产化学与工业》
EI
CAS
CSCD
2006年第3期81-84,共4页
Chemistry and Industry of Forest Products
基金
广东省科技计划重大专项(A301020101)
广东省自然科学基金资助项目(01142)
关键词
厚朴
超临界CO2提取
水蒸气蒸馏
化学成分
Magnolia offwinalis Rehd. et Wils.
supercritical CO2 extraction
steam distillation
chemical constituents
作者简介
曾志（1962-），男，湖南岳阳人，教授，博士，研究方向：有机质谱学在中药有效成分研究中的应用，中药现代化与天然产物化学；E-mail：zhizeng@8cnu．edu．cn；zhizeng@akita-pu．ac．jp。
