摘要
目的:探讨声学造影后大鼠不同时期肝硬化肝实质灰度的时间-强度曲线(TIC)参数在分析肝纤维化与肝硬化中的作用。方法:通过皮下注射四氯化碳建立不同时期大鼠肝硬化模型并分为6周组、8周组、10周组和12周组,以正常大鼠为对照组(每组16只,共80只)。经外周静脉注射声学造影剂后,应用视频分析法形成大鼠肝脏实质灰度的TIC,测量并分析比较各组中的峰值时间(TP)、峰值强度(PI)、峰值减半时间(HT)、曲线下降斜率(DS)、曲线下面积(AUC)和平均渡越时间(MTT)等参数。结果:不同时期大鼠肝硬化模型成功建立,并能动态反映肝硬化发展的病理过程。随着肝硬化程度的加重,PI值、HT值呈逐渐升高的趋势,而DS值则相反(6～12周组与对照组间相比,6、8周组与10、12周组间相比,差异有显著性意义,P<0.01);AUC值与MTT值的变化差异无显著性意义(P>0.05)。结论:声学造影后大鼠肝脏声像图随病变程度加重呈一定规律性变化,而该变化能为TIC所反映,为早期肝硬化的无创性诊断提供了新的可能。
Objective： To investigate the characters of the dynamic sonographic changes of liver cirrhosis in rats after contrast enhancement and evaluate its role in detecting liver fibrosis and cirrhosis. Method： Model of liver cirrhosis was established in 80 rats by subcutaneously injecting CCl4, which were divided into one control group and 4 groups according to modeling time（6, 8, 10 and 12 weeks respectively）. The time-intensity curve of rat＇s parenchyma was drawn with video frequency analysis after ultrasound contrast agent was injected intravenously and time to peak（TP）, peak intensity（PI）, half time of descent（HT）, descending slope（DS）, area under the curve（AUC） and mean transit time（MTT） were measured and compared. Resuits： The models of rat＇s liver cirrhosis in different stages were established successfully and they could reflect the pathological progress of the cirrhosis. With the aggravation of cirrhosis, the values of TP, PI and HT tended to rise gradually while DS was contrary（compared between 6～12 weeks and control groups and between 6, 8 weeks groups and 10, 12 weeks groups, the differences were significant, P〈0.01）. Otherwise, the changes of AUC and MTT were not significant（P〉0.05）. Conclusion： The changes of rats＇ hepatic sonograph present some regularity with the development of cirrhosis, which can be reflected by TIC. It also provides a new possibility for non-invasive diagnosis of liver cirrhosis.
出处
《中国临床医学影像杂志》
CAS
北大核心
2006年第9期523-525,共3页
Journal of China Clinic Medical Imaging
关键词
肝硬化
静脉造影术
liver cirrhosis
phlebography
作者简介
华兴（1975-），男，江苏人，博士在读。
