摘要
目的：回顾性分析1542例因肾脏疾病行经皮肾活检患者的病理类型和临床资料并探讨二者之间的联系．方法：参照WHO（1982年及改良的1995年）肾小球疾病组织学分型方案，结合临床资料、实验室检查结果、光镜、免疫病理及电镜的改变特点，提出初步诊断，最后与临床医师共同讨论确定诊断．结果：患者行肾活检时平均年龄32．5±15．3（6～63）岁，男女之比为1，55：1，原发性肾小球疾病占首位（69．39％），继发性肾小球疾病占26，85％，终末期肾病占2，59％，原发性肾小球疾病的病理类型中最多见为系膜增生性肾小球肾炎（45．05％），其次为局灶节段性肾小球硬化症（16．73％）和IgA肾病（8.32％）．继发性肾小球疾病以狼疮肾炎居首位（14．27％），其次为紫癜性肾炎（7．00％）和乙肝相关性肾炎（1．95％）．引起慢性肾功能不全的病理类型依次为IgA肾病（13．70％）、增生硬化性肾小球肾炎（10．40％）和局灶节段肾小球硬化症（9．10％）．结论：本地区肾脏疾病多见于青壮年，以原发性肾脏疾病最常见，其中系膜增生性肾小球肾炎是最多见的病理类型．继发性肾小球疾病以狼疮肾炎最常见．引起慢性肾功能不全最常见的病理类型为IgA肾病和增生硬化性肾小球肾炎．
AIM： To investigate the relation between renal pathological category and clinical features by analyzing the clinicopathological date in 1542 cases having underwent renal biopsy. METHODS： Pathological classifications were made according to the WHO criteria of 1982 for renal pathology or the modified WHO criteria of 1995 and the clinical data, laboratory results, light microscopy, immune fluorescence and electron microscopy by a panel of pathologists and nephrologists in routine clinicalpathological rounds. RESULTS： The average age at renal biopsy was 32.5 ± 15.3 （6-63） years old in 1542 patients with renal diseases, and the ratio of male to female was 1.55： 1. Primary glomerular diseases （PGD） accounted for 69. 39%, secondary glomerulonephritis （SGN） for 26. 85%, and end-stage renal disease （ESRD） for 2.59%. The PGD in descending order of incidence, were mesangial proliferative glomerulonephritis （ MsPGN, 45.05% ） , focal segmental glomerulosclerosis （ FSGS, 16.73% ） and IgA nephropathy （8.32%）. The SGN in descending order of incidence, were lupus nephritis （ 14.27% ） , purpura nephritis （7.00%） and hepatitis B virus-associated nephritis （ HBVGN, 1.95% ）. The chronic renal failure in descending order of incidence, were IgA nephropathy （ 13.70% ） , proliferative sclerosing glomerulonephritis （ PSGN, 10.40% ） and FSGS （9. 10% ）. CONCLUSION： In our area, renal diseases often happen in young people. PGD is a dominating type in which MsPGN is the most common. In the SGN, lupus nephritis is dominant. The major pathological categories of the causes of chronic renal failure are IgA nephropathy and PSGN.
出处
《第四军医大学学报》
北大核心
2006年第17期1599-1602,共4页
Journal of the Fourth Military Medical University
关键词
肾脏疾病
肾
活组织检查
病理类型
回顾性分析
renal disease
renal
biopsy
pathological category
retrospective analysis
作者简介
杜娟丽，硕士，副主仟医师．Tel：（029）81102169；Email：dujli@163.cn
通讯作者：王汉民，Tel：（029）84775197;Email：whm@medmail，com.cn
