摘要
流感病毒的不断变异是造成流感流行的主要原因。研究表明人流感病毒与禽流感病毒存在密切相关。最近出现的禽流感病毒跨种属感染人的事件,预示引起下一次人间爆发的流感病毒可能直接源于禽流感病毒。因为人类对新出现的病毒缺乏免疫力,开发有效疫苗是预防流感流行的关键。本文对流感病毒疫苗的种类及发展趋势进行阐述。
出处
《日本医学介绍》
2006年第9期424-426,共3页
Progress in Japanese Medicine
参考文献13
-
1Claude H, Francoise M, James P. Immunogenicity and protective efficacy of influenza vaccination [J]. Virus Research.2004, 103(1-2) : 133-138.
-
2Shal , Vincent M J, Compans RW. Enhancement of mucesal immune responses to the influenza virus HA protein by alternative approaches to DNA immunization[J]. Immunobiology. 1999, 200(1): 21 -30.
-
3Bot A, Bot S, Garcia SA. DNA immunization of newborn mice with a plasmid - expressing nucleopmtein of influenza virus[J]. Viral Immunol. 1996,9(4) :207 -210.
-
4Alexander DJ . A review of avian influenza in different bird species[J]. Vet Microbiol 2000,74(1 -2) : 3 - 13.
-
5Munster VJ, Wallensten A, Baas C ,et al. Mallards and highly pathogenic avian influenza ancestral viruses, northern Europe[J]. Emerg Infect Dis. 2005, 11 (10) : 1545 -1551.
-
6Hoffmann E, Lipatov AS, Webby RJ, et al. Role of specific hemagglutinin amino acids in the immunogenicity and protection of H5N1 influenza virus vaccines[ J]. The New England Journal of Medicine, 2005,102(36) : 12915 - 12920.
-
7Treanor JJ, Wilkinson BE, Masseoud F, et al. Safety and immunogenicity of a recombinant hemagglutinln vaccine for H5 influenza in humans[J]. Vaccine. 2001, 19( 13 - 14) :1732 - 1737.
-
8Nicholson KG, Colegate AE, Podda A, et al. Safety and antigenicity of non-adjuvanted and MF59-adjuvanted influenza A/Duck/Singapore/97 (H5N3) vaccine: a randomised trial of two potentlal vaccines against H5N1 influenza[J]. Lancet,2001,357(9272) :1937 - 1943.
-
9Bugacini R, Nicholson KG, Podda A ,et al. Cross-reactivity to highly pathogenic avian influenza H5N1 viruses after vaccination with nonadjuvanted and MF59-adjuvanted influenza A/Duck/Singapore/97 ( H5N3 ) vaccine: a potential priming strategy[J]. Infect Dis ,2005 ,191 (8) : 1210 - 1215.
-
10Treanor JJ,Campbell JD, Zangwill KM, et al. Safety and immunogenicity of an inactivated subvirion influenza a (H5N1) a accine[J]. The New England Journal of Medicine, 2006,354 : 1343 - 1351.
同被引文献29
-
1梁昊宇,曾明.新疫苗和佐剂的临床前安全性评价[J].国际生物制品学杂志,2006,29(4):163-165. 被引量：7
-
2吕进,王希良（审校者）.流感病毒灭活疫苗研究进展[J].国际免疫学杂志,2007,30(2):125-128. 被引量：4
-
3徐晓敬,郭宝平.揭秘甲型H1N1流感疫苗生产流程[EB/OL].http://focus.mz16.cn/jinrijujiao/20090616/101111_2.html,2009-06-16/2009-06-28.
-
4赵铠,揭开甲型H1N1流感疫苗的神秘面纱[EB/OL].http://www.21food.cn/html/news/35/476058.htm.2009-06-30/2009-07-10.
-
5WHO.Swine influenza[EB/OL].(2009-10-12)[2009-10-15].http://www.who.int/csr/don/.434.2009-04-24/ en/index.html.
-
6Centers for Disease Control and Prevention.Human swine influenza investigation[EB/OL].(2009-10-14)[2009-10-15].http://www.cdc.gov/swineflu/updates/investigation-0423209.htm.
-
7Enserink M,Kaiser J.Swine flu outbreak.Devilish dilemmas surround pandemic flu vaccine[J].Science,2009,324(5928):702-705.
-
8Wiley DC,Wilson IA,Skehel JJ.Structural identification of the antibody binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation[J].Nature,1981,289(5796):373-378.
-
9张敏彦,全球甲型H1N1流感疫情及防控的动态[EB/OL].(2009-07-25)[2009-10-16].http://news.xinhuanet.com/ world/2009-09/27/content_12116320.htm.
-
10庄浩滨.甲型流感疫苗接种不良反应[EB/OL].(2009-11-24)[2010-01-06].http://www.sznews.com.
-
1苏振峰.糖尿病患者接种灭活流感病毒疫苗的效果分析[J].中国社区医师（医学专业）,2014,16(22):125-125.
-
2郇丽芳,舒跃龙,张智清.DNA疫苗及其在流感病毒疫苗研究中的应用[J].中华实验和临床病毒学杂志,2007,21(2):194-195.
-
3李茹.接种流感病毒疫苗对预防流行性感冒和减少流行性感冒流行影响的意义[J].实用医技杂志,2012,19(4):381-382. 被引量：3
-
4王树云.肺部感染的疫苗防治进展[J].国外医学（呼吸系统分册）,1999,19(1):15-17. 被引量：6
-
5田玉岭.自体骨髓干细胞移植治疗肝硬化研究进展[J].中国生化药物杂志,2011,32(6):499-502. 被引量：7
-
6张禹.甲型H1N1流感个人防护知识问答[J].家庭医学（上半月）,2009(7):8-9.
-
7于永利.流感病毒广谱中和抗体与广谱流感病毒疫苗[J].微生物学免疫学进展,2013,41(4):1-11.
-
8付鹏.如何应对流感——疫苗和药物哪个更安全[J].健康世界,2012(12):40-41.
-
9邱美珍,方芳,陈则.流感病毒灭活疫苗研究进展[J].生命科学研究,2005,9(4):296-300.
-
10什么方式可以杀灭甲型H1N1流感病毒？[J].中华疾病控制杂志,2009,13(3):386-386.
