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腹腔镜脾切除对难治性ITP治疗的应用价值 被引量:14

Application of laparoscopic splenectomy in treatment of refactory idiopathic thrombocytopenic purpura
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摘要 目的 探讨腹腔镜脾切除术(LS)治疗难治性特发性血小板减少性紫癜(ITP)的可行性和疗效.方法 回顾性分析2002年9月-2006年3月18例难治性ITP(血小板计数<50×10^9/L)行LS的临床资料.结果 1例中转传统开腹手术.17例完成LS,手术时间为52~172min,平均92min;术中出血量30~500mL,平均102mL.3例术中发现副脾并切除.术后1周内血小板上升,胃肠蠕动恢复时间为12~24h,平均住院时间为8d.发生并发症2例(腹壁静脉刺破出血).17例随访2~37个月,1例复发.结论 腹腔镜脾切除术治疗ITP是安全可行的,且临床疗效显著. Objective To investigate the safety and efficacy of laparoscopic splenectomy ( LS ) in treatment of refractory idiopatie thrombocytopenic purpura (ITP). Methods The clinical data of 18 patients with ITP underwent LS from 2002 to 2006 were analyzed retrospectively. Results One case was converted to open surgery. Seventeen patients successfully underwent LS. The mean operation time was 92 (52 - 172 ) minutes, and intraoperative mean blood loss was 102 (30 -500 )mL. At operation an accessory spleen was found in 3 cases and it was excised. The platelet count was elevated rapidly in one week postoperatively , and peristalsis of alimentary tract recovered in 12 to 24 hours after operation in all cases. The mean hospitalization time was 8 days. Complication (puncture of abdominal wall caused bleeding ) occurred in two cases. Seventeen patients were followed up for 2 - 37 months, one patient relapsed. Conclusions LS is a relatively safe and effective measure for treatment of ITP.
出处 《中国普通外科杂志》 CAS CSCD 2006年第8期569-571,共3页 China Journal of General Surgery
关键词 血小板减少性紫癜/治疗 脾切除术 腹腔镜术 Thrombocytopenic Purpura/ther Splenectomy Laparoscopy
作者简介 陈学敏,男,湖北襄樊人,苏州大学附属常州第一人民医院主治医师,主要从事肝胆、腹腔镜临床应用方面的研究. 通讯作者:陈学敏 E-mail:tomuer@163.com.
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参考文献6

  • 1Schwartz J,Leber MD,Gillis S,et al.Long term follow-up after splenectomy performed for immune thrombocytopenic purpura (ITP)[J].Am J Hematol,2003,72(2):94-98.
  • 2Gadenstatter M,Lamprecht B,Klingler A,et al.Splenectomy versus medical treatment for idiopathic thrombocytopenic purpura[J].Am J Surg,2002,184(6):606-610.
  • 3Pamuk GE,Pamuk ON,Baslar Z,et al.Overview of 321 patients with idiopathic thrombocytopenic purpura.Retrospective analysis of the clinical features and response to therapy[J].Ann Hematol,2002,81 (8):436-440.
  • 4Friedman RL,Fallas MJ,Carroll BJ,et al.Laparoscopic splenectomy for ITP.The gold standard[J].Surg Endosc,1996,10(10):991-995.
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  • 6王德炳 主译.克氏外科学[M](第15版)[M].北京:人民卫生出版社,2000.1014-1015.

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