摘要
本研究从分子水平研究血管通抗动脉粥样硬化的作用机制。实验用日本种雄性鹌鹑给予高脂饲料１２周，形成动脉粥样硬化后给予血管通３０天，取血用放射免疫法测定内皮素和降钙素基因相关肽，观察血管通对动脉粥样硬化模型血浆内皮素和降钙素基囚相关肽以及总胆固醇和甘油三酯的影响。结果表明：模型形成过程中，其血浆内皮素升高，降钙素基因相关肽降低，总胆固醇和甘油三酯明显升高；血管通可降低模型的血浆内皮素（Ｐ＜０．０５）及降低总胆固醇（Ｐ＜０．００１）和甘油三酯（Ｐ＜０．００１），升高其降钙素基固相关肽（Ｐ＜０．０５）。上述结果提示：血管通抗动脉粥样硬化机制可能与其通过降低血浆内皮素和升高降钙素基因相关肽有关。
This paper mainly reported the antiatherogenic mechanism of action of Xueguantong on molecular level. After being established by feeding with high fat diet for 12 weeks, the quail atherosis models were given Xueguantong for 30 days. Then, determining their plasma endothelin and calcitonin gene-related peptide(CGRP) with radioimmunoassay (RIA) and observing the effects of Xueguantong on plasma endothelin and CGRP in quail atherosis models. Results showed that the plasma endothelin increased and CGRP decreased during quail atherosis formation. The plasma endothelin was decreased(P < 0 . 05) and CGRP was increased (p <0 . 05) by using Xueguantong.It suggested that one of antiatherogenic mechanisms of Xueguantong was decreasing the endothelin and increasing the CGRP.
出处
《中国中西医结合杂志》
CSCD
北大核心
1996年第8期483-485,共3页
Chinese Journal of Integrated Traditional and Western Medicine
