摘要
研究了固定有多粘菌素B(Po lym yx in B,PM B)短肽的聚苯乙烯微球对血浆中细菌内毒素的亲和吸附性能,讨论了不同吸附条件对吸附性能的影响。用纯种大白鼠作为实验动物,建立内毒素血症动物模型,用固定有PM B短肽的聚苯乙烯微球对动物模型进行血液灌流实验,观察该吸附剂血液灌流清除血浆中内毒素的功效,考察了接有PM B短肽的聚苯乙烯微球的血液相容性及其对蛋白的影响。实验结果表明,采用血液灌流吸附疗法成功地清除动物模型血液中的内毒素,而且,固定有多粘菌素B的特异吸附剂具有良好的血液相容性。
In this paper, the adsorbent properties of Polymyxin B immobilized polystyrene microbeads to remove endotoxin from plasma were studied and the factors that affected the absorption of endotoxin were discussed. The rabbit models of endoxemia were established,which were used in hemoperfusion. The experiment results indicated that the novel affinity adsorbent could remove endotoxin from plasma effectively. Moreover. the results also showed that Polymyxin B immobilized polystyrene microbeads was a fine biomaterial of hemoperfusion as well as exhibited a satisfactory blood compatibility.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2006年第4期832-835,共4页
Journal of Biomedical Engineering
基金
教育部访问学者基金资助项目(200204)
重庆市攻关课题资助(2002-6613)
关键词
多粘菌素B
内毒素
血液灌流
血液相容性
Polymyxin B（PMB） Endotoxin Hemoperfusion Blood compatibility
作者简介
通讯作者。E-mail；sxcai@cqu．edu．cn
