摘要
目的:探讨腰椎间盘源性腰痛程度与病变髓核及脑脊液中多种介质含量的关系。方法:腰椎间盘源性腰痛行髓核摘除手术患者,31例术前检测脑脊液中P物质和降钙素基因相关肽含量;20例术中取出髓核组织测定磷脂酶A2活性。结果:所有手术患者脑脊液中神经肽类介质(P物质、降钙素基因相关肽)含量高于正常对照组,并与疼痛程度相关。病变椎间盘髓核中磷脂酶A2活性水平明显高于自体血和健康人,其疼痛程度与磷脂酶A2活性水平显著相关。结论:椎间盘源性腰痛患者脑脊液中神经肽类介质含量较正常人高,椎间盘髓核中炎症介质与椎间盘源性腰痛的程度有关。
Objective： To analyze the relationship between of discogenic low back pain and inflammtory factors in nucleus and CSF. Methods： The phospholipase Aa （PLAa ） activity was assayed in 20 nucleus samples obtained from discectomy; the CSF level of substance P （SP） and calcitonin gene-releted peptide （CGRP） was assayed in 31 patients with discogenic low back pain. Results： The level of PLAz of suffered discs was significantly higher than that in blood and normal discs; the SP and CGRP levels in CSF in patients with discogenic low back pain were also significantly higher than those in healthy people. Conclusion： The inflammatory factors and neuropeptide play important roles in the pathogenesis of discogenic low back pain.
出处
《中国疼痛医学杂志》
CAS
CSCD
北大核心
2006年第3期138-139,共2页
Chinese Journal of Pain Medicine
