摘要
以间甲酚为原料,经加压氧气催化氧化得到2-甲基苯醌,再在加压和二甲基亚砜溶剂条件下与1,3-丁二烯进行Diels-Alder加成反应,并在一锅中直接氧化脱氢生成维生素K3,产品总收率为75%。本方法具有原料廉价易得,产品收率高,污染排放较少,反应条件温和,容易工业化等优点。
m- Cresol was chosen as raw material which oxidized by oxygen under pressure to give 2 - methyl -1,4- benzoquione, The product was then subject to a Diels- Alder addition with 1,3- butadiene in the presence of DMSO as solvent, and the addition product was subsequently to oxidative dehydrogenation to give vitamin K3,,The total yield of product reached 75 %. The process possess the advantages of cheap in the raw material, high in the yields, less in pollution produced and mild in the reaction conditions, which is adapt to industrialization.
出处
《江西化工》
2006年第2期12-14,共3页
Jiangxi Chemical Industry
