摘要
Novozym e-435催化10-羟基癸酸进行自缩聚反应得到线性聚酯,端基分别是羟基(—OH)和羧基(—COOH),在三乙胺催化下,分别用α-溴代丙酰溴和三甲基氯硅烷(TMSCL)进行端基官能化生成一个单官能度的大分子引发剂,在CuC l/2,2′-联吡啶(bpy)催化体系中,引发甲基丙烯酸环氧丙酯(GMA)的原子转移自由基反应(ATRP),得到聚(10-羟基癸酸酯)/聚甲基丙烯酸环氧丙酯(PHDA-b-PGMA)AB型两亲性嵌段共聚物,其结构及分子量(分布)通过核磁共振和凝胶渗透色谱(GPC)确证.此AB型两亲性嵌段共聚物在水溶液中能自组装形成纳米粒子,用原子力显微镜(AFM)观察粒子的形状和大小.
The diblock copolymers poly （10-hydroxydecanoic acid ）-block poly （glycidyl methacrylate ） （PHDA-b-PGMA） were synthesized by combining enzymatic condensation polymerization of 10-hydroxydecanoic acid （HDA） and atom transfer radical polymerization （ATRP） of glycidyl methacrylate （GMA）. PHDA was firstly obtained via enzymatic condensation polymerization catalyzed by Novozyme-435. Subsequently one end of PHDA chains was modified by reaction with c^-bromopropionyl bromide and the other was protected by chlorotrimethylsilane （TMSCL）, respectively, the resulting monofunctional macroinitiator was used in the ATRP of GMA using CuCI/2,2＇-bipyridine（bpy） as the catalyst system to afford the diblock copolymers including biodegradable PHDA blocks and well-defined PGMA blocks. Polymer nanospheres were prepared by the self-assembly behaviors of the amphiphilic diblock copolymers PHDA-b-PGMA in aqueous solvent.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2006年第8期1575-1578,共4页
Chemical Journal of Chinese Universities
基金
国家自然科学基金(批准号:20574028)资助
关键词
酶促缩聚
原子转移自由基聚合
嵌段共聚物
自组装
Enzymatic polymerization
Atom transfer radical polymerization（ATRP）
Block copolymer
Selfassembly
作者简介
陈亮（1963年出生），男，副教授，硕士生导师，从事医学影像学研究．E-mail：chenliangMD@163．com.
联系人：王静嫒（1950年西生），女，教授，博士生导师，从事功能高分子材料合成研究．E-mail：jingyuan@jlu．edu．cn
