摘要
目的:观察拉莫三嗪添加治疗难治性癫癎的疗效、用药方法、剂量及副作用。方法:对54例难治性癫癎患者进行添加拉莫三嗪治疗,观察其疗效。结果:拉莫三嗪添加治疗难治性癫癎,总有效率达83％,37例(69％)患者发作停止。对全面性发作有效率达83％,对部分性发作及部分性发作继发全面性强直阵挛性发作有效率达80％。平均有效剂量96．8±27．3mg／d,37例无发作病例平均剂量为77．8±17．5 mg／d。2例加量12．5 mg／d后发作加重,减量后控制良好。除1例发生轻微皮肤瘙痒外,无中枢神经系统及其他副作用,满意度为96％。结论:拉莫三嗪添加治疗难治性癫癎有良好疗效,副作用轻微,一天一次用药效果可靠,一般患者有效剂量在150mg／d内。
Objective： To evaluate the antiepileptic efficacy , offer its method , dosage and side effects of added lamotrigine. Methods： In 54 patients with refractory epilepsy , lamotrigine was added to the treatment. Results：Seizure frequency reduction by ≥50 % was found in 83% of all patients, and seizure free was note in 37 patients （69%）. The effectiveness ratio of lamotrigine was 83 % and 80% in patients with generalized seizure and those with partial seizure（including generalized seizure secondly to partial seizure） respectively. The average effective dosage was 96.8±27.3mg/ d. The average dosages for 37 patients with seizure free was 77.8± 17.5 mg/ d. Seizure frequency became more in 2 patients after the dosage of lamotrigine increasing 12.5 mg/d and better seizure control was achieved after the dosage decreasing from their present dosage. There is no side effects upon the central nervous system and others except for slightly skin scratching was found in one patient. Most patients felt better psychologically and their sleep state got better. The satisfactory ratio of patients was 96 %. Condusion： The lamotrigine is eff- ctive as an additive to therapy for patients with refractory epilepsy. Side effects of lamotrigine is slight. The effective dosage for most patients is within 150mg/d.
出处
《临床神经电生理学杂志》
2006年第4期222-224,228,共4页
Journal of Clinical Electroneurophysiology
关键词
拉莫三嗪
难治性
癫痫
Lamotrigine
Refractory
Epilepsy
